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Intervertebral disc degeneration (IDD) is a common disease in orthopedics, and its pathogenesis is complicated. The main pathological changes are cell apoptosis and extracellular matrix degradation. Clinical therapies are mainly symptomatic and cannot cure diseases at the etiological level. IDD targeted therapy has become the focus of current research due to its small side effects and broad prospects. The apoptosis of nucleus pulposus cells caused by activation of the Fas signaling pathway is an important cause of IDD. It affects IDD's pathophysiological process through genetic factors and is closely related to the pathogenesis of IDD inflammation, immunity, and abnormal vascular growth. Targeting Fas signaling inhibition may be a new type of therapy to slow down the process of IDD effectively. This paper reviews Fas apoptotic pathway, etiology of IDD, the relationship between Fas pathway and IDD, and targeted inhibition of Fas pathway in the treatment of IDD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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