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Objective To investigate the expression level and clinical significance of serum miR-21 and Peli1 mRNA in peripheral blood mononuclear cells (PBMC) of patients with autoimmune premature ovarian insufficiency (aPOI). Methods A total of 26 patients untreated and initially diagnosed as autoimmune POI (aPOI group) and 30 healthy young females (control group), visited during April 2018 to October 2019 in Zhujiang Hospital of Southern Medical University, were included in present study. The general data of each subject were recorded. The expression levels of serum miR-21 and PBMC Peli1 mRNA were detected by qRT-PCR, and the serum sex hormone [estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH)], anti-Mullerian hormone (AMH), thyroid hormones and immune-related indicators were evaluated. Uterus and ovary index of all subjects were assessed by ultrasonography. Results The expression levels of serum miR-21 and PBMC Peli1 mRNA were significantly lower in aPOI group than those in control group (0.60±0.14 vs. 1.01±0.07; 0.30±0.14 vs. 1.63±0.54, P<0.05), and Peli1 mRNA was positively related with miR-21 (r=0.719, P<0.05). Compared with control group, aPOI group showed earlier menarche age, shorter menstrual period, fewer gravidity and parity, less contents of E2 and AMH, smaller uterus and ovaries; while longer menstrual cycle, higher levels of FSH and LH, and the number of positive menopausal symptoms and immune indexes were significantly higher than those in control group (P<0.05). MiR-21 and Peli1 mRNA were positively related to E2, AMH, the size of uterus and ovarian volume, respectively; and negatively related to FSH, LH, and the number of positive immune indexes. Conclusions The serum miR-21 is positively related to the decreased expression level of PBMC Peli1 in aPOI patients, and both miR-21 and Peli1 might be involved in the pathogenesis of aPOI, therefore show some values for the auxiliary diagnosis of aPOI.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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