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Application progress of induced pluripotent stem cells in Alzheimer's disease
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Meng-Jie Li, Li-Na Zhang, Ying-Hui Shang, Han-Chang Huang, Feng-Xue Lao*
Medical Journal of Chinese People’s Liberation Army | 2021, 46(2) : 193 - 199
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(2): 193-199
• Review •
Application progress of induced pluripotent stem cells in Alzheimer's disease
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Meng-Jie Li, Li-Na Zhang, Ying-Hui Shang, Han-Chang Huang, Feng-Xue Lao*
Affiliations
  • Beijing Key Laboratory of Bioactive Substances and Functional Foods, Institute of Functional Factors and Brain Sciences, Beijing Union University, Beijing 100191, China
Published: 2021-02-28 doi: 10.11855/j.issn.0577-7402.2021.02.14
Outline
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Alzheimer's disease (AD) is one of the common chronic neurodegenerative diseases, and characterized mainly by the deposition of amyloid β-protein (Aβ), hyperphosphorylation of tau protein, and neuronal and synaptic loss. Currently approved drugs can only alleviate the symptoms and cannot completely cure the disease. Stem cells have specific abilities of self-renewal, proliferation, differentiation and reprogramming. In particular, the induced pluripotent stem cells (iPSCs) developed in recent years have provided a new research strategy for the treatment of AD. The combination of iPSCs technology with gene editing,3D-like organs, and biomaterial scaffolds has resulted in a new approach to the recognition and treatment of AD. This review mainly summarizes the latest applications of iPSCs in AD, including the application of disease modeling in the research of pathogenesis of AD and early biomarker detection, the combination of iPSCs and 3D scaffold in cell therapy, and the application of iPSCs in high-throughput drug screening.

Alzheimer's disease  /  induced pluripotent stem cells  /  cell model  /  cell transplantation  /  drug screening
Meng-Jie Li, Li-Na Zhang, Ying-Hui Shang, Han-Chang Huang, Feng-Xue Lao. Application progress of induced pluripotent stem cells in Alzheimer's disease[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (2) : 193 -199 . DOI: 10.11855/j.issn.0577-7402.2021.02.14
Funding
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  • National Natural Science Foundation of China(31471587)
  • Discipline Positioning Ten Leading Research Direction Special Project(ZK40201902)
  • Research and Innovation Funding Program for Graduate Students of Beijing United University(YZ2020K001)
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Year 2021 volume 46 Issue 2
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.02.14
  • Receive Date：2020-04-14
  • Online Date：2025-12-26
  • Published：2021-02-28
Article Data
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History
  • Received：2020-04-14
  • Revised：2021-01-20
Funding
National Natural Science Foundation of China(31471587)
Discipline Positioning Ten Leading Research Direction Special Project(ZK40201902)
Research and Innovation Funding Program for Graduate Students of Beijing United University(YZ2020K001)
Affiliations
    Beijing Key Laboratory of Bioactive Substances and Functional Foods, Institute of Functional Factors and Brain Sciences, Beijing Union University, Beijing 100191, China

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光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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