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Research progress of treatment process on endocrine adverse reactions caused by immune checkpoint inhibitors
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Jing-Mei Luo, Zhong-Ce Yang, Li Pan, Li-Hua Zhang*
Medical Journal of Chinese People’s Liberation Army | 2021, 46(2) : 200 - 206
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(2): 200-206
• Review •
Research progress of treatment process on endocrine adverse reactions caused by immune checkpoint inhibitors
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Jing-Mei Luo, Zhong-Ce Yang, Li Pan, Li-Hua Zhang*
Affiliations
  • Department of General Practice, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
Published: 2021-02-28 doi: 10.11855/j.issn.0577-7402.2021.02.15
Outline
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Immune checkpoint inhibitors (ICIs) are new anticancer agents in recent years, and are monoclonal autoantibodies specifically targeting T cell inhibitory receptors, may enhance the anti-tumor effect by blocking negative regulatory factors that inhibit T cell function. ICIs can generate peculiar immunotoxicity, called immune-related adverse events (irAEs), which can potentially affect many tissues, the most frequent toxic reactions to endocrine system include hypophysitis, thyroid dysfunction, adrenal insufficiency, and autoimmune diabetes mellitus. The treatment process of such adverse reactions has been further elaborated in present review through the introduction of the endocrine irAEs induced by ICIs in immunotherapy, aiming to provide clinicians with ideas for the treatment of endocrine irAEs.

immune checkpoint inhibitors  /  immune-related adverse effects  /  hypophysitis  /  thyroid diseases  /  adrenal insufficiency  /  autoimmune diabetes mellitus
Jing-Mei Luo, Zhong-Ce Yang, Li Pan, Li-Hua Zhang. Research progress of treatment process on endocrine adverse reactions caused by immune checkpoint inhibitors[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (2) : 200 -206 . DOI: 10.11855/j.issn.0577-7402.2021.02.15
Funding
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  • National Natural Science Foundation of China(81960156)
  • High Level Health Technology Personnel Training Project of Yunnan Province(D-2018044)
  • Health Science and Technology Program of Yunnan Province(2017NS018)
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Year 2021 volume 46 Issue 2
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.02.15
  • Receive Date：2020-09-16
  • Online Date：2025-12-26
  • Published：2021-02-28
Article Data
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History
  • Received：2020-09-16
  • Revised：2020-12-28
Funding
National Natural Science Foundation of China(81960156)
High Level Health Technology Personnel Training Project of Yunnan Province(D-2018044)
Health Science and Technology Program of Yunnan Province(2017NS018)
Affiliations
    Department of General Practice, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

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