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Research progress of mesoporous silica in the treatment of military bone trauma
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Peng Li1, 2, Qiong Bu3, Guo-Ding Cao1, 2, Peng Liu1, 2, Wan-Shun Fang4, Jun Liu1, 5, Jun Liu6, Xu-Sheng Li2, *
Medical Journal of Chinese People’s Liberation Army | 2021, 46(2) : 175 - 180
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(2): 175-180
• Review •
Research progress of mesoporous silica in the treatment of military bone trauma
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Peng Li1, 2, Qiong Bu3, Guo-Ding Cao1, 2, Peng Liu1, 2, Wan-Shun Fang4, Jun Liu1, 5, Jun Liu6, Xu-Sheng Li2, *
Affiliations
  • 1The First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou 730030, China
  • 2Department of Joint Surgery, Institute of Orthopedics, the 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China
  • 3Department of Respiratory Medicine, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
  • 4Graduate Department of Shandong First Medical University, Jinan 250000, China
  • 5Department of Urology, the 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China
  • 6Department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, China
Published: 2021-02-28 doi: 10.11855/j.issn.0577-7402.2021.02.11
Outline
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Bone injury is the most common type of war wound, and different from ordinary open bone injury. The war wound bone injury caused by high-energy weapons has the characteristics of deep bleeding site, coagulation dysfunction, multi bacteria infection and large bone defect area, so it is difficult to be treated in battlefield. Mesoporous silica is a new type of inorganic nano biomaterial, which is widely used in bleeding treatment and bone tissue engineering due to its high specific surface area, large porosity and easy modification. Compared with the traditional materials for the treatment of traumatic bone injury, mesoporous silica has the advantages of local sustained hemostasis, broad-spectrum, sustained-release and strong mechanical support. Its main research direction is the composite and multifunctional materials. The surface functionalized mesoporous silica has the functions of hemostasis and infectious bone defect repair. However, there are still some problems such as unclear biological distribution in vivo and hepatorenal toxicity in large doses of mesoporous silica materials; in terms of preparation technology, there are still some problems such as unclear selection of pore size and shape of materials for promoting bone formation. Based on the actual needs of the treatment of war-induced bone injuries, the multifunctional, easy-to-use and portable properties of new mesoporous silica materials are reviewed in this paper.

mesoporous silica  /  modifiable  /  bone injury  /  battlefield care
Peng Li, Qiong Bu, Guo-Ding Cao, Peng Liu, Wan-Shun Fang, Jun Liu, Jun Liu, Xu-Sheng Li. Research progress of mesoporous silica in the treatment of military bone trauma[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (2) : 175 -180 . DOI: 10.11855/j.issn.0577-7402.2021.02.11
Funding
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  • National Natural Science Foundation of China(81371983)
  • Military Logistics Research Project(CWH17J009)
  • Lanzhou Talent Innovation and Entrepreneurship Project(2019-RC-65)
  • Fundamental Research Funds for the Central Universities(31920200018)
  • Military Medical Science and Technology Youth Development Program(19QNP047)
  • Youth Science and Technology Foundation of Gansu Province(18JR3RA410)
  • Health Industry Research Plan Project of Gansu Province(GSWSKY2018-21)
  • Health Industry Research Plan Project of Gansu Province(GSWSKY2019-94)
  • Natural Science Foundation of Shaanxi Province(2020JM-339)
Appendix
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Year 2021 volume 46 Issue 2
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167
70
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.02.11
  • Receive Date：2020-11-14
  • Online Date：2025-12-26
  • Published：2021-02-28
Article Data
Affiliations
History
  • Received：2020-11-14
  • Revised：2020-12-24
Funding
National Natural Science Foundation of China(81371983)
Military Logistics Research Project(CWH17J009)
Lanzhou Talent Innovation and Entrepreneurship Project(2019-RC-65)
Fundamental Research Funds for the Central Universities(31920200018)
Military Medical Science and Technology Youth Development Program(19QNP047)
Youth Science and Technology Foundation of Gansu Province(18JR3RA410)
Health Industry Research Plan Project of Gansu Province(GSWSKY2018-21)
Health Industry Research Plan Project of Gansu Province(GSWSKY2019-94)
Natural Science Foundation of Shaanxi Province(2020JM-339)
Affiliations
    1The First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou 730030, China
    2Department of Joint Surgery, Institute of Orthopedics, the 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China
    3Department of Respiratory Medicine, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
    4Graduate Department of Shandong First Medical University, Jinan 250000, China
    5Department of Urology, the 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China
    6Department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, China

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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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