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Research progress of long non-coding RNA in liver fibrosis
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Chun-Yan Zhang, Yu-Xin Yan, Jie Liang, Menggen Si-Li-Mu, Yue-Hong Ma*
Medical Journal of Chinese People’s Liberation Army | 2021, 46(2) : 186 - 192
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(2): 186-192
• Review •
Research progress of long non-coding RNA in liver fibrosis
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Chun-Yan Zhang, Yu-Xin Yan, Jie Liang, Menggen Si-Li-Mu, Yue-Hong Ma*
Affiliations
  • Department of Basic Medical, the Inner Mongolia Medical University, Hohhot 010059, China
Published: 2021-02-28 doi: 10.11855/j.issn.0577-7402.2021.02.13
Outline
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Long non-conding RNA (lncRNA) is a group of RNA with a length of more than 200 nt and no function of coding protein, and plays a physiological function at the level of heredity, transcription and post transcription. LncRNA can regulate multiple signal pathways. For example, hepatic fibrosis-associated lncRNA1 (LFAR1) promotes the activation of hepatic stellate cells(HSC) through transforming growth factor-β (TGF-β) signal pathway in the progress of liver fibrosis; HOX transcript antisense intergenic RNA (Hotair) promotes the activation of HSC as ceRNA; lncRNA-p21 inhibits the activation of HSC as ceRNA;maternally expressed gene 8 (MEG8) can inhibit the activation of HSC in hepatic cell by inhibiting Notch pathway. With more and more people's understanding of the function of lncRNA in liver fibrosis, it is expected to become a new target in the early diagnosis, prognosis judgment and treatment of fibrosis. This article reviews the research progress of lncRNA in liver fibrosis..

long non-conding RNA  /  hepatic fibrosis  /  hepatic stellate cell  /  signal pathway
Chun-Yan Zhang, Yu-Xin Yan, Jie Liang, Menggen Si-Li-Mu, Yue-Hong Ma. Research progress of long non-coding RNA in liver fibrosis[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (2) : 186 -192 . DOI: 10.11855/j.issn.0577-7402.2021.02.13
Funding
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  • National Natural Science Foundation of China(81960759)
  • Inner Mongolia Natural Science Foundation(2019MS08010)
Appendix
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Year 2021 volume 46 Issue 2
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.02.13
  • Receive Date：2020-06-23
  • Online Date：2025-12-26
  • Published：2021-02-28
Article Data
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History
  • Received：2020-06-23
  • Revised：2020-12-07
Funding
National Natural Science Foundation of China(81960759)
Inner Mongolia Natural Science Foundation(2019MS08010)
Affiliations
    Department of Basic Medical, the Inner Mongolia Medical University, Hohhot 010059, China

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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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