Home Journals Articles Updates About
CN
image
收藏切换
Clinical efficacy and safety of antithymocyte globulin prophylaxis for graft recipients in deceased donor kidney re-transplantation
收藏切换
PDF
Xiao-Dong Yan1, 2, Jun Lin2, Jian Zhang2, Jun-Nan Xu3, Zhi-Jia Liu3, Xin Hong4, Chang-Qin Chen3, Tao Yu3, Qiang Wang2, 3, *
Medical Journal of Chinese People’s Liberation Army | 2021, 46(2) : 136 - 141
Less
收藏切换
Medical Journal of Chinese People’s Liberation Army | 2021, 46(2): 136-141
• Clinical Research •
Clinical efficacy and safety of antithymocyte globulin prophylaxis for graft recipients in deceased donor kidney re-transplantation
Full
Xiao-Dong Yan1, 2, Jun Lin2, Jian Zhang2, Jun-Nan Xu3, Zhi-Jia Liu3, Xin Hong4, Chang-Qin Chen3, Tao Yu3, Qiang Wang2, 3, *
Affiliations
  • 1Postgraduate School, Hebei North University, Zhangjiakou, Hebei 075000, China
  • 2Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  • 3Organ Transplant Institute, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China
  • 4Department of Urology, Peking University International Hospital, Beijing 102206, China
Published: 2021-02-28 doi: 10.11855/j.issn.0577-7402.2021.02.05
Outline
收藏切换

Objective To investigate the efficacy and safety of antithymocyte globulin (ATG) in the immune induction of deceased donor renal re-transplantation. Methods The clinical data of 20 renal re-transplantation patients treated with ATG from June 2017 to November 2020, were retrospectively studied. The safety was assessed with T lymphocyte subsets, pulmonary infection, and bone marrow suppression. The efficacy was assessed with acute rejection (AR) and delayed graft function (DGF). Results The study contained 15 males and 5 females. The average age was 45.7 (25-71) years; 6 patients were positive for prestored antibody and 14 negative antibody; 17 patients received a second transplantation, 3 did a third transplantation. T lymphocytes decreased more than 70% in average induced by ATG on the 1st day after surgery and gradually recovered to 50% of the amount on the 3rd day after surgery (P<0.01). Two weeks after surgery, the number of T lymphocytes recovered to the pretransplant level. NK cells showed a continuous decline (P<0.01). There were 5 patients (25.0%) who suffered AR, 1 patient (5.0%) did DGF, 7 patients(35.0%) presented with pulmonary infection, 5 patients (25.0%) presented with bone marrow suppression, and no ATG allergic reaction cases. The median follow-up period was 17.6 (6-53) months. During the follow-up period, 19 patients (95.0%) survived with allograft and 1 (5.0%) died. Conclusions ATG can significantly suppress the activation and proliferation of T cells, reduce the incidence of AR, and improve the short-term functional recovery of allograft with kidney re-transplantation. ATG induction does not increase the incidence of infection, and the clinical safety of ATG application is reliable.

kidney re-transplantation  /  immune induction  /  anti-human thymocyte immunoglobulin  /  sensitized recipients
Xiao-Dong Yan, Jun Lin, Jian Zhang, Jun-Nan Xu, Zhi-Jia Liu, Xin Hong, Chang-Qin Chen, Tao Yu, Qiang Wang. Clinical efficacy and safety of antithymocyte globulin prophylaxis for graft recipients in deceased donor kidney re-transplantation[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (2) : 136 -141 . DOI: 10.11855/j.issn.0577-7402.2021.02.05
Funding
Less
  • National Natural Science Foundation of China(82070765)
  • Medical Immunology Key Laboratory Fund Project(NKMI2020K05)
Appendix
Less
Year 2021 volume 46 Issue 2
PDF
182
78
Cite this Article
BibTeX
Article Info
doi: 10.11855/j.issn.0577-7402.2021.02.05
  • Receive Date：2020-11-11
  • Online Date：2025-12-26
  • Published：2021-02-28
Article Data
Affiliations
History
  • Received：2020-11-11
  • Revised：2021-01-13
Funding
National Natural Science Foundation of China(82070765)
Medical Immunology Key Laboratory Fund Project(NKMI2020K05)
Affiliations
    1Postgraduate School, Hebei North University, Zhangjiakou, Hebei 075000, China
    2Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
    3Organ Transplant Institute, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China
    4Department of Urology, Peking University International Hospital, Beijing 102206, China

Corresponding:

References
Share
https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/10.11855/j.issn.0577-7402.2021.02.05
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House