PDF
Full
Outline
Osteosarcoma is one of the most common primary malignant tumors in children and adolescents, and its development mechanism in human body has not been clearly explained by scholars. With the in-depth study of immunology, tumor immunity has gradually become a hot spot in the field of tumor research. A large number of studies have shown that programmed death protein-1 (PD-1)and its ligand 1 (PD-L1) can mediate immunosuppression, weaken the killing effect of immune cells on tumor cells, and lead to immune escape of tumor cells, thus promoting the development of tumor. This paper reviews the immune escape mechanism of PD-1/PD-L1 in osteosarcoma and the latest progress of PD-1/PD-L1 axis in the treatment of osteosarcoma, aiming to provide theoretical reference for understanding the role of PD-1/PD-L1 in osteosarcoma and developing new drugs for the treatment of osteosarcoma.
PDF
229
96
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
