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Research progress on the relationship between haptoglobin and diabetic kidney disease
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Yu-Jing Ke1, 2, Zhe-Yi Dong2, Xiang-Mei Chen1, 2, *
Medical Journal of Chinese People’s Liberation Army | 2021, 46(1) : 84 - 88
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(1): 84-88
• Review •
Research progress on the relationship between haptoglobin and diabetic kidney disease
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Yu-Jing Ke1, 2, Zhe-Yi Dong2, Xiang-Mei Chen1, 2, *
Affiliations
  • 1School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
  • 2Department of Nephrology, General Hospital of Chinese PLA/Institute of Nephrology of PLA/State Key Laboratory of Kidney Diseases/National Chronic Nephropathy Clinical Research Center/Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China
Published: 2021-01-28 doi: 10.11855/j.issn.0577-7402.2021.01.14
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Haptoglobin (HP) is a kind of plasma glycoprotein with genetic polymorphism, secreted mainly in liver and has two alleles of HP1 and HP2, can form three potential genotypes: HP1-1, HP2-1 and HP2-2, which has the function of binding to free hemoglobin and antioxidation. At present, many studies have shown that HP may be a potential biomarker of diabetic kidney disease. Because of the special structure and function of HP, it has certain advantages in early diagnosis and prognosis prediction of diabetic nephropathy. The relationship has been mainly reviewed in present paper between the expression level of HP and its genotypes in the occurrence, development, diagnosis and prognosis prediction of diabetic nephropathy.

haptoglobin  /  diabetic kidney disease  /  genotype  /  early diagnosis  /  prognosis
柯雨景, 董哲毅, 陈香美. 触珠蛋白与糖尿病肾病的关系研究进展. 解放军医学杂志, 2021 , 46 (1) : 84 -88 . DOI: 10.11855/j.issn.0577-7402.2021.01.14
Yu-Jing Ke, Zhe-Yi Dong, Xiang-Mei Chen. Research progress on the relationship between haptoglobin and diabetic kidney disease[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (1) : 84 -88 . DOI: 10.11855/j.issn.0577-7402.2021.01.14
Funding
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  • National Key Research and Development Program(2018YFC1704203)
  • Important National Science and Technology Specific Projects(2019ZX09201-005)
  • National Natural Science Foundation of China(81700629)
  • Science and Technology Project of Beijing(D171100002817002)
  • Big Data Program from Chinese PLA General Hospital(2019MBD-053)
Appendix
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Year 2021 volume 46 Issue 1
645
285
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.01.14
  • Receive Date：2020-06-12
  • Online Date：2025-12-26
  • Published：2021-01-28
Article Data
Affiliations
History
  • Received：2020-06-12
  • Revised：2020-10-22
Funding
National Key Research and Development Program(2018YFC1704203)
Important National Science and Technology Specific Projects(2019ZX09201-005)
National Natural Science Foundation of China(81700629)
Science and Technology Project of Beijing(D171100002817002)
Big Data Program from Chinese PLA General Hospital(2019MBD-053)
Affiliations
    1School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
    2Department of Nephrology, General Hospital of Chinese PLA/Institute of Nephrology of PLA/State Key Laboratory of Kidney Diseases/National Chronic Nephropathy Clinical Research Center/Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China

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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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