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Research progress on the action mechanism of curcumin in the treatment of traumatic arthritis
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Peng Liu1, 2, Li Ren3, Ping Zhen2, Peng Li1, 2, Yan-Feng Chang2, Guo-Ding Cao1, 2, Xu-Sheng Li2, Hao-Qiang Zhang2, Jun Liu4, *
Medical Journal of Chinese People’s Liberation Army | 2021, 46(1) : 76 - 83
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(1): 76-83
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Research progress on the action mechanism of curcumin in the treatment of traumatic arthritis
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Peng Liu1, 2, Li Ren3, Ping Zhen2, Peng Li1, 2, Yan-Feng Chang2, Guo-Ding Cao1, 2, Xu-Sheng Li2, Hao-Qiang Zhang2, Jun Liu4, *
Affiliations
  • 1Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China
  • 2Department of Joint Surgery, Institute of Orthopedics, the 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China
  • 3College of Medical Technology, Lanzhou University of Technology, Lanzhou 730050, China
  • 4Department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University (Northwest Hospital), Xi’an 710004, China
Published: 2021-01-28 doi: 10.11855/j.issn.0577-7402.2021.01.13
Outline
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Traumatic arthritis (TA) is a kind of osteoarthritis secondary to joint trauma, and its pathogenesis is not clear at present. It is mainly related to the apoptosis of chondrocytes involved in a variety of cytokines and related signal pathways. Curcumin has anti-inflammatory, anti-oxidant and anti-apoptotic effects. Curcumin is used to treat TA mainly by inhibiting oxidase, scavenging free radicals' antioxidant effects, inhibiting the anti-inflammatory effects of cyclooxygenase, lipoxygenase and various inflammatory mediators, and acting on various signal transduction pathways to inhibit apoptosis of chondrocytes. This paper describes some of the biological functions of curcumin, and introduces its related mechanism of action in the treatment of TA.

traumatic arthritis  /  curcumin  /  chondrocytes  /  articular cartilage  /  signal pathway  /  inflammatory factors
刘鹏, 任莉, 甄平, 李鹏, 常彦峰, 曹国定, 李旭升, 张浩强, 刘军. 创伤性关节炎及其姜黄素治疗作用机制的研究进展. 解放军医学杂志, 2021 , 46 (1) : 76 -83 . DOI: 10.11855/j.issn.0577-7402.2021.01.13
Peng Liu, Li Ren, Ping Zhen, Peng Li, Yan-Feng Chang, Guo-Ding Cao, Xu-Sheng Li, Hao-Qiang Zhang, Jun Liu. Research progress on the action mechanism of curcumin in the treatment of traumatic arthritis[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (1) : 76 -83 . DOI: 10.11855/j.issn.0577-7402.2021.01.13
Funding
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  • Military Logistics Research Project(CWH17J009)
  • Military Medical Science and Technology Youth Development Program(19QNP047)
  • Lanzhou Talent Innovation and Entrepreneurship Project(2019-RC-65)
  • Health Industry Research Plan Project of Gansu Province(GSWSKY2018-21)
  • Central University Innovation Team Project(31920200018)
  • Natural Science Foundation of Shaanxi Province(2020JM-339)
  • Youth Science and Technology Foundation of Gansu Province(1606RJYA300)
  • Youth Science and Technology Foundation of Gansu Province(20JR5RA588)
  • Natural Science Foundation of Gansu Province(1606RJZA208)
  • Natural Science Foundation of Gansu Province(18JR3RA403)
Appendix
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Year 2021 volume 46 Issue 1
953
470
Cite this Article
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.01.13
  • Receive Date：2020-07-24
  • Online Date：2025-12-26
  • Published：2021-01-28
Article Data
Affiliations
History
  • Received：2020-07-24
  • Revised：2020-12-09
Funding
Military Logistics Research Project(CWH17J009)
Military Medical Science and Technology Youth Development Program(19QNP047)
Lanzhou Talent Innovation and Entrepreneurship Project(2019-RC-65)
Health Industry Research Plan Project of Gansu Province(GSWSKY2018-21)
Central University Innovation Team Project(31920200018)
Natural Science Foundation of Shaanxi Province(2020JM-339)
Youth Science and Technology Foundation of Gansu Province(1606RJYA300)
Youth Science and Technology Foundation of Gansu Province(20JR5RA588)
Natural Science Foundation of Gansu Province(1606RJZA208)
Natural Science Foundation of Gansu Province(18JR3RA403)
Affiliations
    1Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China
    2Department of Joint Surgery, Institute of Orthopedics, the 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China
    3College of Medical Technology, Lanzhou University of Technology, Lanzhou 730050, China
    4Department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University (Northwest Hospital), Xi’an 710004, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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