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Changes of ocular fundus hemodynamics and retinal and choroidal thickness after tail suspension for 2 weeks in rats
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Yu-Bo Gong1, Hong-Wei Zhao1, Fei-Long Song1, Yu Zhang1, Xiao-Hua Guo1, Ling Luo1, Yong-Jie Xu2, *, Yuan-Yuan Shi1, *
Medical Journal of Chinese People’s Liberation Army | 2021, 46(1) : 7 - 10
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(1): 7-10
• Basic Research •
Changes of ocular fundus hemodynamics and retinal and choroidal thickness after tail suspension for 2 weeks in rats
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Yu-Bo Gong1, Hong-Wei Zhao1, Fei-Long Song1, Yu Zhang1, Xiao-Hua Guo1, Ling Luo1, Yong-Jie Xu2, *, Yuan-Yuan Shi1, *
Affiliations
  • 1Department of Ophthalmology, Strategic Support Force Medical Center of Chinese PLA, Beijing 100101, China
  • 2Department of Ultrasound Diagnosis, Strategic Support Force Medical Center of Chinese PLA, Beijing 100101, China
Published: 2021-01-28 doi: 10.11855/j.issn.0577-7402.2021.01.02
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Objective To investigate the effects of simulated 2-week microgravity on the ocular fundus hemodynamics of central retinal artery and the retinal and choroidal thickness in autogenous rats. Methods Eight healthy SD rats were designed in self-control, designed for the control before tail suspension, the tail suspension for 1, 4, 7 and 14 d. A rat model of simulated microgravity method was established by tail suspension. The peak maximum systolic velocity (PSV) of central retinal artery(CRA) in rats was detected and analyzed by color Doppler ultrasonography. The retinal and choroidal thicknesses were measured by the enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT). Results The PSV value in each different period after tail suspension was decreased compared with that in the control before tail suspension (P<0.05). There was no significant difference in PSV value between the tail suspension for 1 d and both the tail suspension for 4 d and 7 d (P>0.05), but there was a significant difference between the tail suspension for 1 d and the tail suspension for 14 d (P<0.05). There was no significant difference in retinal thickness between the control and the each different periods after tail suspension (P>0.05). The choroidal thickness was lower in the control before tail suspension than that in each different period after tail suspension (P<0.05). Compared with the tail suspension for 1 d, the choroidal thickness of the rats was significantly increased in the tail suspension for 4, 7 and 14 d respectively (P<0.05). Conclusions Two-week simulated microgravity environment has significant effects on the fundus blood flow and choroid thickness in rats, but has no obvious effect on the retinal thickness in rats. The fundus flow velocity would decrease and choroid thickness would increase with the prolongation of the tail suspension time.

simulated microgravity  /  central retinal artery  /  hemodynamics  /  retinal thickness  /  choroidal thickness
Yu-Bo Gong, Hong-Wei Zhao, Fei-Long Song, Yu Zhang, Xiao-Hua Guo, Ling Luo, Yong-Jie Xu, Yuan-Yuan Shi. Changes of ocular fundus hemodynamics and retinal and choroidal thickness after tail suspension for 2 weeks in rats[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (1) : 7 -10 . DOI: 10.11855/j.issn.0577-7402.2021.01.02
Funding
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  • National Environmental Protection Key Laboratory Open Fund of Environmental Sense Organ Stress and Health(19ZX84)
  • Incubation Project of Military Medical Science and Technology Youth Training Programme(15QNP051)
  • Incubation Project of Military Medical Science and Technology Youth Training Programme(16QNP035)
Appendix
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Year 2021 volume 46 Issue 1
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143
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.01.02
  • Receive Date：2020-03-04
  • Online Date：2025-12-26
  • Published：2021-01-28
Article Data
Affiliations
History
  • Received：2020-03-04
  • Revised：2020-11-14
Funding
National Environmental Protection Key Laboratory Open Fund of Environmental Sense Organ Stress and Health(19ZX84)
Incubation Project of Military Medical Science and Technology Youth Training Programme(15QNP051)
Incubation Project of Military Medical Science and Technology Youth Training Programme(16QNP035)
Affiliations
    1Department of Ophthalmology, Strategic Support Force Medical Center of Chinese PLA, Beijing 100101, China
    2Department of Ultrasound Diagnosis, Strategic Support Force Medical Center of Chinese PLA, Beijing 100101, China

Corresponding:

*Xu Yong-Jie, E-mail: ;
Shi Yuan-Yuan, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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