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Research progress on the role of adenosine pathway in tumor immunity
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Yang Yu1, 2, An-Qi Zhang3, Lei Gao1, 2, Zhen-Yu Yin1, 2, Qian Liu1, 2, Yu-Ping Bai1, 2, Le Liu1, 2, Wen-Bo Qi1, 2, Hao Chen1, *
Medical Journal of Chinese People’s Liberation Army | 2021, 46(6) : 616 - 622
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(6): 616-622
• Review •
Research progress on the role of adenosine pathway in tumor immunity
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Yang Yu1, 2, An-Qi Zhang3, Lei Gao1, 2, Zhen-Yu Yin1, 2, Qian Liu1, 2, Yu-Ping Bai1, 2, Le Liu1, 2, Wen-Bo Qi1, 2, Hao Chen1, *
Affiliations
  • 1Department of Tumor Surgery, Lanzhou University Second Hospital, Lanzhou 730030, China
  • 2Department of Tumor Surgery, the Second Clinical Medical College of Lanzhou University, Lanzhou 730030, China
  • 3Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China
Published: 2021-06-28 doi: 10.11855/j.issn.0577-7402.2021.06.14
Outline
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A variety of mechanisms help tumor escape from the recognition and killing by the body immune system. In recent years, the adenosine pathway has been found to play an important role in tumor immune evasion. Adenosine is produced from extracellular adenosine triphosphate (ATP) in the presence of two ectonucleotidases (CD39 and CD73), and exerts specific functions through binding to its receptors [mainly adenosine A2A receptor (A2AR)]. Studies have suggested that the adenosine pathway can be over-activated in the tumor micro-environment, and thus promoting tumor development and progression by generating the immuno-suppressive signals. This review talked about the role of the adenosine pathway in regulating tumor immunity and its potential clinical application value. At the same time, the latest research evidence of adenosine-pathway-related targeted drugs is evaluated and summarized to provide a comprehensive reference for understanding the significance of the adenosine pathway in cancer management.

adenosine  /  immune evasion  /  CD73  /  CD39  /  adenosine A2A receptor  /  review
Yang Yu, An-Qi Zhang, Lei Gao, Zhen-Yu Yin, Qian Liu, Yu-Ping Bai, Le Liu, Wen-Bo Qi, Hao Chen. Research progress on the role of adenosine pathway in tumor immunity[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (6) : 616 -622 . DOI: 10.11855/j.issn.0577-7402.2021.06.14
Funding
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  • Key Talents Project of Gansu Province(2019RCXM020)
  • Science and Technology Project of Chengguan District of Lanzhou City(2019RCCX0034)
  • Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital(CY2017-ZD01)
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Year 2021 volume 46 Issue 6
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.06.14
  • Receive Date：2021-01-09
  • Online Date：2025-12-20
  • Published：2021-06-28
Article Data
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History
  • Received：2021-01-09
  • Revised：2021-04-28
Funding
Key Talents Project of Gansu Province(2019RCXM020)
Science and Technology Project of Chengguan District of Lanzhou City(2019RCCX0034)
Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital(CY2017-ZD01)
Affiliations
    1Department of Tumor Surgery, Lanzhou University Second Hospital, Lanzhou 730030, China
    2Department of Tumor Surgery, the Second Clinical Medical College of Lanzhou University, Lanzhou 730030, China
    3Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China

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