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Recent advances in vaccine development of severe acute respiratory syndrome coronavirus 2
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Xi-Jing Qian, Cai-Hong Wan, Ping Zhao, Zhong-Tian Qi*
Medical Journal of Chinese People’s Liberation Army | 2021, 46(7) : 710 - 717
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(7): 710-717
• Review •
Recent advances in vaccine development of severe acute respiratory syndrome coronavirus 2
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Xi-Jing Qian, Cai-Hong Wan, Ping Zhao, Zhong-Tian Qi*
Affiliations
  • Department of Biomedical Defense, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China
Published: 2021-07-28 doi: 10.11855/j.issn.0577-7402.2021.07.11
Outline
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The outbreak of coronavirus disease 2019 (COVID-19) has become a global pandemic. The pathogen responsible for this disease is a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It belongs to coronavirus family, a pathogen similar to SARS and Middle East respiratory syndrome (MERS), and manifests strong infectivity and pathogenicity to progress into severe pneumonia. Till now, there is no specific therapeutic drug targeting against this virus. With the rapid spread and deterioration of the epidemic situation, vaccination has become an urgent need. This review introduces the immune defense mechanism of human body against coronavirus briefly, set forth the key viral spike protein for coronavirus vaccine development, and then summarize the recent advances/progresses and potential challenges in safety and efficacy of vaccine development for SARS-CoV-2.

coronavirus disease 2019  /  coronavirus  /  S protein  /  vaccine
Xi-Jing Qian, Cai-Hong Wan, Ping Zhao, Zhong-Tian Qi. Recent advances in vaccine development of severe acute respiratory syndrome coronavirus 2[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (7) : 710 -717 . DOI: 10.11855/j.issn.0577-7402.2021.07.11
Funding
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  • National Special Projects of Infectious Diseases(2017ZX10304403-003)
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Year 2021 volume 46 Issue 7
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.07.11
  • Receive Date：2021-01-29
  • Online Date：2025-12-20
  • Published：2021-07-28
Article Data
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History
  • Received：2021-01-29
  • Revised：2021-05-03
Funding
National Special Projects of Infectious Diseases(2017ZX10304403-003)
Affiliations
    Department of Biomedical Defense, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China

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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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