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Research progress on role of ferroptosis suppressor protein 1 in human diseases
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Hui-Ping Lu, Yi-Wu Dang, Gang Chen*
Medical Journal of Chinese People’s Liberation Army | 2021, 46(7) : 731 - 736
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(7): 731-736
• Review •
Research progress on role of ferroptosis suppressor protein 1 in human diseases
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Hui-Ping Lu, Yi-Wu Dang, Gang Chen*
Affiliations
  • Department of Pathology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
Published: 2021-07-28 doi: 10.11855/j.issn.0577-7402.2021.07.14
Outline
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Ferroptosis suppressor protein 1 (FSP1), confirmed as a ferroptosis-resistant factor recently, plays a key role in the oncogenesis and progress of human diseases, such as breast cancer, ovarian cancer, lung cancer, hepatocellular carcinoma,melanoma, lymphoma, leukemia, copper resistance, severe acute pancreatitis, and diabetes. FSP1 is regarded as a double-edged sword according to previous studies. Mechanically, FSP1 triggers caspase-independent apoptosis via its C-terminal fragments,nuclear translocation, or over-expression, and inhibits ferroptosis through FSP1-CoQ10-NAD(P)H axis, being independent of the glutathione (GSH)-GPX4 axis. The research progress in action mechanism of FSP1 in human diseases is briefly described in this review for providing novel preventative and therapeutic target molecules for human diseases.

ferroptosis suppressor protein 1  /  apoptosis-inducing factor mitochondrial-associated 2  /  glutathione peroxidase 4  /  ferroptosis
Hui-Ping Lu, Yi-Wu Dang, Gang Chen. Research progress on role of ferroptosis suppressor protein 1 in human diseases[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (7) : 731 -736 . DOI: 10.11855/j.issn.0577-7402.2021.07.14
Funding
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  • Innovation Project of Guangxi Graduate Education(YCBZ2020045)
  • Innovation Project of Guangxi Graduate Education(JGY2019050)
  • Guangxi Medical and Health Appropriate Technology Development, Popularization and Application Project(S2020031)
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Year 2021 volume 46 Issue 7
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.07.14
  • Receive Date：2021-02-04
  • Online Date：2025-12-20
  • Published：2021-07-28
Article Data
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History
  • Received：2021-02-04
  • Revised：2021-03-05
Funding
Innovation Project of Guangxi Graduate Education(YCBZ2020045)
Innovation Project of Guangxi Graduate Education(JGY2019050)
Guangxi Medical and Health Appropriate Technology Development, Popularization and Application Project(S2020031)
Affiliations
    Department of Pathology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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