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Objective To explore the relationship between platelet function and disease progression and prognosis in patients with cerebral hemorrhage without antiplatelet agents. Methods A retrospective analysis was performed on the clinical data of 129 patients with intracerebral hemorrhage who were admitted to the Neurosurgical Department, the First Affiliated Hospital of Chongqing Medical University from January 2015 to December 2019. These patients were divided into two groups: rebleeding group after intracerebral hemorrhage (n=53) and non-rebleeding group (n=76). The relation of thrombelastograph parameters including R value, K value, Angle of view, and the inhibition rates of arachidonic acid (AA) and adenosine diphosphate (ADP) under the condition without use of antiplatelet drugs at admission and their correlation with Glasgow Coma Scale score were compared between the two groups. Results The AA inhibition rate (P=0.015) and ADP inhibition rate (P=0.025) in rebleeding group were statistically higher than those in non-rebleeding group. AA inhibition rate of platelet function (P=0.022) and ADP inhibition rate (P=0.030) in rebleeding death group were statistically higher than those in survival group. AA inhibition rate (r=–0.183,P=0.038) and ADP inhibition rate (r=–0.175, P=0.047) were negatively correlated with Glasgow Coma Scale score. Conclusions Thrombelastographic detection of platelet function can be used as an early warning indicator to assist the assessment of the risk of rebleeding and prognosis in patients with intracerebral hemorrhage.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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