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Objective To explore the correlation of the serum C-reactive protein/albumin ratio (CRP/ALB, CAR) and homocysteine/high-density lipoprotein cholesterol (HCY/HDL-C) to the morbid change of coronary artery disease. Methods A total of 577 patients who underwent coronary angiography in the Department of Cardiology of the 904th Hospital of PLA Joint Logistics Support Force from January 2018 to December 2019 were divided into two groups according to the results of coronary angiography: non-coronary heart group (n=245) and coronary atherosclerotic heart disease group (coronary heart disease group,n=332). The coronary heart disease group was further divided into two subgroups: mild coronary artery disease subgroup (Gensini score <30, n=183) and severe coronary artery disease subgroup (Gensini score ≥30, n=149). The serum levels of CRP, ALB, HCY,HDL-C and other indicators of patients in each group were detected, and CAR and HCY/HDL-C were calculated, and then the logistic regression analysis, Pearson correlation analysis and receiver operating characteristic (ROC) curve analysis were carried out to analyze the independent risk factors for coronary heart disease and severe coronary artery lesion. Results The levels of CAR and HCY/HDL-C were significantly higher in coronary heart disease group than those in non-coronary heart disease group with statistically significant difference (P<0.05). Multivariate logistic regression analysis showed that CAR, HCY/HDL-C, age, hypertension, and gender were the independent risk factors for coronary heart disease and severe coronary artery disease. Pearson correlation analysis showed that CAR and HCY/HDL-C were positively correlated with Gensini score (r=0.427, P<0.01; r=0.247,P<0.01). The results of ROC curve analysis showed that CAR, HCY/HDL-C and both their combination had predictive values for severe coronary heart disease, and the AUC of combined the both factors was statistically higher than that of any single factor alone(P<0.05). Conclusions Elevated levels of CAR and HCY/HDL-C may predict the severe coronary artery disease. The diagnostic value of combined the two factors is better than a single factor alone, so can be used for the diagnosis and condition evaluation of coronary artery disease.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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