PDF
Full
Outline
Objective To explore the impact of severe calcification on the abnormal hemodynamics based on CT-fractional flow reserve (CT-FFR) diagnosis, and evaluate the diagnostic significance of pericoronary fat attenuation index (FAI) on the abnormal hemodynamics of severely calcified coronary artery. Methods The clinical data of patients were retrospectively analyzed who underwent a coronary computed tomography angiography (CCTA) examination within one month before an invasive FFR examination from January 2017 to December 2019 in the First Medical Center of Chinese PLA General Hospital. Regarding invasive FFR≤0.8 as the gold standard of hemodynamically abnormal coronary artery disease (CAD), patients were assigned to FFR≤0.8 group and FFR>0.8 group. The coronary artery calcium score (CACS), degree of major coronary branch stenosis, pericoronary FAI and CT-FFR were measured and compared. Invasive FFR≤0.8 represents the presence of lesion-specific hemodynamic significant CAD. According to the quartiles of CACS, patients were further divided into mildly-moderately calcified (1st-3rd quartiles) and severely calcified (4th quartile) stratification. The diagnostic efficacy for abnormal coronary hemodynamics was analyzed only with CT-FFR and combined with pericoronary FAI detection between the two groups. Results A total of 99 patients with 124 main coronary arteries were included (37 in FFR≤0.8 group, and 87 in FFR>0.8 group). In terms of vascular characteristics, statistically significant differences existed between FFR≤0.8 group and FFR>0.8 group in CACS (85.80, 95%CI 6.750~0.977 vs. 42.50, 95%CI 0.600~110.200, P<0.05), degree of major coronary branch stenosis (63.8%±9.9% vs. 57.6%±9.5%, P<0.01), pericoronary FAI(–73.3±9.5 vs. –80.6±7.5, P<0.01) and CT-FFR (0.77±0.04 vs. 0.86±0.04, P<0.01). The diagnostic efficacy of CT-FFR was lower for severe calcified vessels than for the vessels with mild to moderate calcification (AUC=0.767, 95%CI 0.581~0.899 vs.AUC=0.936, 95%CI 0.865~0.976, P<0.05), while the pericoronary FAI showed good diagnostic efficacy for the severe calcified vessels (AUC=0.850, 95%CI 0.676~0.952). CT-FFR combined with pericoronary FAI improved the diagnostic efficacy than using CT-FFR alone (AUC=0.917, 95%CI 0.760~0.985 vs. AUC=0.767, 95%CI 0.581~0.899, P=0.046). Conclusion For severe calcified vessels, the effectiveness declined of CT-FFR in the diagnosis of significant coronary ischemia, while combined implementation of FAI may improve the diagnosis of CAD with abnormal hemodynamics.
PDF
198
74
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
