Objective To analyze the correlation of plasma fibrinogen (Fib) and blood lipid composition to the progression of non-culprit coronary lesions (NCCLs) in CHD patients after percutaneous coronary intervention (PCI). Methods The clinical data were collected and retrospectively analyzed of 210 patients admitted from January 2017 to December 2017 in the Department of Cardiovascular Medicine of the First Hospital of Lanzhou University, received the first PCI treatment, and repeated the coronary angiography (CAG) before December 31, 2020 (the interval between two operations should be at least 6 months). According to whether the NCCLs progressed, 210 patients were divided into progressive group (n=99) and non-progressive group (n=111), and then, according to the degree of NCCLs progression, patients in progressive group were further divided into three subgroups: mild(n=42), moderate (n=35) and severe (n=22) progressive subgroup. The baseline clinical data were compared between the patients in progressive group and in non-progressive group, and among the patients in mild, moderate and severe progression subgroups. The correlation of the plasma Fib and blood lipid composition to the progression of NCCLs, and the risk factors affecting the progression of NCCLs were analyzed. Results There were no statistical difference between progressive group and non-progressive group in gender, smoking history, drinking history, hypertension history, hyperlipidemia history, heart failure, and admission blood pressure(P>0.05), but the mean age was higher in progressive group than that in non-progressive group, and more patients with diabetes in progressive group than those in non-progressive group, and there existed statistically significant differences (P<0.05). The plasma levels of Fib, cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and non-high density lipoprotein cholesterol (non-HDL-C) were higher in progressive group than those in non-progressive group with statistically significant differences (P<0.05).There existed no significant difference (P>0.05) between the two groups in the levels of triglyceride (TG) and HDL-C; with the increasing in the severity of NCCLs, plasma Fib, TG, LDL-C, and non-HDL-C increased gradually in the mildly, moderately, and severely advanced subgroups, while the plasma level of HDL-C decreased gradually, but no statistical difference existed among the subgroups (P>0.05); Fib, TC, LDL-C, non-HDL-C, and D-dimer were positively correlated with the NCCLs progression. And also,Fib was positively correlated with TC, LDL-C, and non-HDL-C. Gender, age, and diabetes history can be used as risk factors for the progression of NCCLs with OR values of 2.284, 1.052, and 0.293, respectively. Conclusion The plasma Fib and blood lipid composition are correlated with the progression of NCCLs, and Fib is also correlated with some lipid components, but is not a risk factor for NCCLs progression.