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Objective To compare the clinicopathological features, differential diagnosis and treatment between perirenal angiomyolipoma (AML) and liposarcoma. Methods Eleven cases of AML and thirty-nine cases of liposarcoma around the kidney from Peking University International Hospital from January 2015 to December 2020 were reviewed in terms of clinical manifestations, imaging examination, pathological morphology, immunophenotype and treatment follow-up. Results The tumors in both groups were close to the kidney, and the imaging signs of renal defect were not distinctive enough to diagnose correctly.Perirenal AML was mainly female (P=0.003), the age of onset was younger than liposarcoma (P<0.001). Most of perirenal AML were single (90.9%, 10/11) and primary (100.0%, 11/11), the histomorphology was mostly accompanied by vascular hyaline degeneration(63.6%, 7/11), and Melan-A and HMB45 were positive by immunohistochemistry. While liposarcoma was often multiple (51.3%,20/39) and recurrent (79.5%, 31/39), Ki-67, P16, CDK4, MDM2 were more highly expressed than AML (P<0.05), and MDM2 gene was amplified. There was no significant difference in the maximum diameter and necrosis between the two groups (P>0.05). Conclusions Retroperitoneal perirenal AML and liposarcoma have similar imaging features, and gender, age, tumor number,primary/recurrent character, histomorphology, protein expression and gene amplification detection are helpful to differentiate them.Liposarcoma needs more extensive resection, active treatment and follow-up.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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