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Research progress of exosomes in the treatment of intervertebral disc degeneration
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Ming-Qiang Liu1, 2, Hai-Wei Chen1, 2, Guang-Zhi Zhang1, 2, Xue-Wen Kang1, 2, *
Medical Journal of Chinese People’s Liberation Army | 2021, 46(8) : 831 - 836
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(8): 831-836
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Research progress of exosomes in the treatment of intervertebral disc degeneration
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Ming-Qiang Liu1, 2, Hai-Wei Chen1, 2, Guang-Zhi Zhang1, 2, Xue-Wen Kang1, 2, *
Affiliations
  • 1Department of Orthopaedics, the Second Hospital of Lanzhou University, Lanzhou 730030, China
  • 2Key Laboratory of Orthopedics of Gansu Province, Lanzhou 730030, China
Published: 2021-08-28 doi: 10.11855/j.issn.0577-7402.2021.08.15
Outline
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Intervertebral disc degeneration (IDD) is a common orthopedic disease characterized by reduction of nucleus pulposus cells and degradation of extracellular matrix. Its specific pathogenesis is not clear. The current treatment can only improve the clinical symptoms of patients, but can not delay or reverse the process of degeneration. Therefore, to find an effective method to repair IDD has become the main goal of current research. In recent years, exosomes have gradually become a research hotspot in the field of regenerative medicine. Exosomes carrying a large number of nucleic acids, proteins, lipids, cytokines and other bioactive molecules participate in the information transmission between different cells and play an important role in regulating the biological functions of receptor cells. Studies have confirmed that exosomes can inhibit the apoptosis and inflammatory reaction of nucleus pulposus cells, promote the proliferation and regeneration of nucleus pulposus cells, and have the potential to cure IDD. In this paper, the characteristics and functions of exosomes from different cell sources and its effect and mechanism in IDD repair were summarized, in order to provide reference for the subsequent studies.

intervertebral disc degeneration  /  nucleus pulposus cell  /  exosomes  /  research progress
Ming-Qiang Liu, Hai-Wei Chen, Guang-Zhi Zhang, Xue-Wen Kang. Research progress of exosomes in the treatment of intervertebral disc degeneration[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (8) : 831 -836 . DOI: 10.11855/j.issn.0577-7402.2021.08.15
Funding
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  • Natural Science Foundation of Gansu Province(2020-0405-JCC-1568)
  • "Cuiying Science and Technology Innovation Project" of the Second Hospital Affiliated to Lanzhou University(CY2019-MS10)
  • Special Fund for Doctoral Education in the Second Hospital Affiliated to Lanzhou University in 2019(YJS-BD-09)
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Year 2021 volume 46 Issue 8
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.08.15
  • Receive Date：2021-05-08
  • Online Date：2025-12-19
  • Published：2021-08-28
Article Data
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History
  • Received：2021-05-08
  • Revised：2021-06-10
Funding
Natural Science Foundation of Gansu Province(2020-0405-JCC-1568)
"Cuiying Science and Technology Innovation Project" of the Second Hospital Affiliated to Lanzhou University(CY2019-MS10)
Special Fund for Doctoral Education in the Second Hospital Affiliated to Lanzhou University in 2019(YJS-BD-09)
Affiliations
    1Department of Orthopaedics, the Second Hospital of Lanzhou University, Lanzhou 730030, China
    2Key Laboratory of Orthopedics of Gansu Province, Lanzhou 730030, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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