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Objective To explore the clinical characteristics and antimicrobial resistance of low respiratory tract infection with Streptococcus pneumonia (S. pneumonia) to provide the basis for clinical treatment. Methods The clinical characteristics of patients diagnosed with S. pneumoniae lower respiratory tract infection admitted to the 980st Hospital of the PLA Joint Logistics Support Force from January 2014 to December 2018 were analyzed. The strains were identified by MA120 system and optochin test,antimicrobial susceptibility testing was carried out by using or E-test method, and the statistical analysis was performed by means of WHONET 5.6 and SPSS 20.0. Results Among the 934 patients with S. pneumoniae infection, the mean age was (1.2±1.2) years,71.07% occurred in autumn and winter, 74.86% had elevated WBC count and 85.16% had high serum C-reactive protein (CRP) level in the children and the mean age was (61.6±19.6) years, 94 patients (45.63%) were ≥65 years old, 149 (72.33%) had underlying diseases, 58.25% occurred in autumn and winter, 77.67% had elevated WBC count and 83.98% had high serum CRP level in the adult patients. The isolated 934 S. pneumoniae strains were 100% sensitive to vancomycin, linezolid and meropenem. The strains from both children and adult had kept highly susceptible to penicillin, and the resistance rate to penicillin was lower than 1%; the resistance rates to amoxicillin/clavulanate, cefotaxime sodium, ceftriaxone sodium, cefepime and levofloxacin were lower than 6%; the resistance rates to erythromycin, azithromycin, tetracycline, clindamycin were more than 80%, and its resistance rates to clindamycin and cefuroxim showed increasing tread in both adults and children. Mean 5-year resistance rate of S. pneumoniae strains isolated from children to cefuroxim was significantly higher than that of strains from adults (P<0.05). Conclusions S. pneumoniae has high resistance rate to macrolides antibiotics, and is not suitable for clinical treatment; S. pneumoniae keeps better sensitivities to penicillin, which can be used to treat S. pneumoniae infection. The resistance rates of S. pneumoniae strains isolated from adults and children to cefuroxim are all high, and show increasing tread, and therefore it is necessary to reasonably choose antibiotics to control bacterial resistance.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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