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Research progress of stereotactic ablation in treatment of Parkinson’s disease
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Chun-Yu Yin1, Rui Zong2, Long-Sheng Pan2, Xue-Mei Li1, *
Medical Journal of Chinese People’s Liberation Army | 2021, 46(9) : 946 - 953
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(9): 946-953
• Review •
Research progress of stereotactic ablation in treatment of Parkinson’s disease
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Chun-Yu Yin1, Rui Zong2, Long-Sheng Pan2, Xue-Mei Li1, *
Affiliations
  • 1Department of Cadre Diagnosis and Treatment, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  • 2Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Published: 2021-09-28 doi: 10.11855/j.issn.0577-7402.2021.09.17
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Stereotactic ablation or surgery known as the lesioning therapies (LT) is a method to treat nervous system diseases by destroying specific tissue structures in the brain through stereotactic minimally invasive technology, mainly consisting of magnetic resonance guided focused ultrasound surgery (MRgFUS), gamma knife stereotactic radiosurgery (GK) and radiofrequency thermal ablation (RF). For Parkinson's disease (PD) patients with poor drug response, LT can significantly improve the clinical symptoms (such as stiffness, tremor, dyskinesia, etc.), reduce drug dosage and improve the long-term quality of life,and is an important alternative to deep brain stimulation (DBS). Fully understanding the mechanism, characteristics, advantages and disadvantages and applicable population of the different methods of LT is of great guiding significance for formulating an individualized treatment plan. The research progress of MRgFUS, GK and RF in LT in the treatment of PD in recent years were reviewed, and the therapeutic effects and adverse reactions of different methods and targets have been summarized in present paper,so as to provide some reference for the selection of clinical operation scheme in the future.

stereotactic ablation  /  magnetic resonance guided focused ultrasound surgery (MRgFUS)  /  radiofrequency thermal ablation  /  gamma knife stereotactic radiosurgery  /  Parkinson's disease
Chun-Yu Yin, Rui Zong, Long-Sheng Pan, Xue-Mei Li. Research progress of stereotactic ablation in treatment of Parkinson’s disease[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (9) : 946 -953 . DOI: 10.11855/j.issn.0577-7402.2021.09.17
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  • Research Project on Health Care of the Logistics Support Department of the Central Military Commission(17BJ39)
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Year 2021 volume 46 Issue 9
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.09.17
  • Receive Date：2021-07-19
  • Online Date：2025-12-19
  • Published：2021-09-28
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History
  • Received：2021-07-19
  • Revised：2021-08-10
Funding
Research Project on Health Care of the Logistics Support Department of the Central Military Commission(17BJ39)
Affiliations
    1Department of Cadre Diagnosis and Treatment, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
    2Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China

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