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Analysis of risk factors for the progression of white matter hyperintensities in the non-demented elderly
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Li-Ying Zhuang, Song Qiao*, Jun-Jun Wang, Qi-Lun Lai, Lu Liu, Yue Lou, Lin Cheng, Ye-Jia Mo, Yu Jin
Medical Journal of Chinese People’s Liberation Army | 2021, 46(9) : 912 - 916
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(9): 912-916
• Clinical Research •
Analysis of risk factors for the progression of white matter hyperintensities in the non-demented elderly
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Li-Ying Zhuang, Song Qiao*, Jun-Jun Wang, Qi-Lun Lai, Lu Liu, Yue Lou, Lin Cheng, Ye-Jia Mo, Yu Jin
Affiliations
  • Department of Neurology, Zhejiang Hospital, Hangzhou 310013, China
Published: 2021-09-28 doi: 10.11855/j.issn.0577-7402.2021.09.11
Outline
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Objective To analysis the risk factors for the progression of white matter hyperintensities (WMHs) in the non-demented elderly. Methods A total of 263 non-demented elderly who completed baseline and 3-year follow-up T2 FLAIR scans were screened from the Alzheimer's Disease Neuroimaging Initiative (ADNI)-1 cohort. They were divided into the progressive group(n=66) and non-progressive group (n=197) according to the progression of WMHs. The baseline demographic data, cardiovascular disease history, apolipoprotein E (apoE) genotype, cognitive function and WMHs volumes at baseline and three-year follow-up were compared between the two groups. The risk factors for the progression of WMHs in the non-demented elderly were evaluated by logistic regression analysis. Results The age, the proportion of coronary heart disease, the WMHs volume at baseline and three-year follow-up in WMHs progressive group were higher than those in non-progressive group, and the scores of immediate memory of auditory verbal learning test and trail making test-B were significantly lower than those in non-progressive group, and the differences were statistically significant (P<0.05). Age correlated positively with baseline WMHs volume and WMHs volume at three-year follow-up (rs=0.273, P<0.001; rs=0.306, P<0.001). Multivariate logistic regression analysis showed that age ≥80 years and a history of coronary heart disease were independent risk factors for the progression of WMHs (OR=2.257, 95%CI 1.219-4.178, P=0.010;OR=2.556, 95%CI 1.048-6.234, P=0.039). Conclusion Age ≥80 years and a history of coronary heart disease are independent risk factors for the progression of WMHs in the non-demented elderly.

non-demented elderly  /  white matter hyperintensities  /  risk factors  /  age
Li-Ying Zhuang, Song Qiao, Jun-Jun Wang, Qi-Lun Lai, Lu Liu, Yue Lou, Lin Cheng, Ye-Jia Mo, Yu Jin. Analysis of risk factors for the progression of white matter hyperintensities in the non-demented elderly[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (9) : 912 -916 . DOI: 10.11855/j.issn.0577-7402.2021.09.11
Funding
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  • National Health and Family Planning Commission Research Foundation(WKJ-ZJ-1809)
  • Zhejiang Science and Technology Planning Project(2018C37132)
  • Natural Science Foundation of Zhejiang Province(LQ19H090006)
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Year 2021 volume 46 Issue 9
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128
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.09.11
  • Receive Date：2021-06-01
  • Online Date：2025-12-19
  • Published：2021-09-28
Article Data
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History
  • Received：2021-06-01
  • Revised：2021-08-21
Funding
National Health and Family Planning Commission Research Foundation(WKJ-ZJ-1809)
Zhejiang Science and Technology Planning Project(2018C37132)
Natural Science Foundation of Zhejiang Province(LQ19H090006)
Affiliations
    Department of Neurology, Zhejiang Hospital, Hangzhou 310013, China

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