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Research progress in mechanism of IKKε and TBK1 in obesity, diabetes and NAFLD
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Xiang-Hong Wang1, Xiu-Lan Zou2, *, Qian He2
Medical Journal of Chinese People’s Liberation Army | 2021, 46(10) : 1051 - 1055
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(10): 1051-1055
• Review •
Research progress in mechanism of IKKε and TBK1 in obesity, diabetes and NAFLD
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Xiang-Hong Wang1, Xiu-Lan Zou2, *, Qian He2
Affiliations
  • 1Department of Endocrinology, the Third Clinical Medical College of Three Gorges University/Gezhouba Central Hospital of Sinopharm, Yichang, Hubei 443000, China
  • 2Department of Geriatrics, the People's Hospital of China Three Gorges University/the First Hospital of Yichang, Yichang, Hubei 443000, China
Published: 2021-10-28 doi: 10.11855/j.issn.0577-7402.2021.10.16
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TANK binding kinase 1 (TBK1) and IKKε, are new members of the IKK family. They are important regulators of nuclear factor κB (NF-κB) signaling pathway and play an important role in metabolic disease. IKKε and TBK1 not only reduce the sensitivity of β adrenergic receptors to catecholamines in adipocytes of obese mice, reduce the level of second messenger cAMP,but also regulate the regeneration of pancreatic β cells. Blocking the IKKε and TBK1 signaling pathways can promote adipose tissue energy consumption, reduce the expression of chronic inflammatory factors in adipocytes, enhance insulin sensitivity, reduce insulin resistance, reduce body weight, and prevent obesity caused by high fat diet. In this review, we reviewed the structure and function of TBK1 and IKKε, as well as the molecular mechanisms of TBK1 and IKKε in the regulation of metabolism in obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD). Finally, we discussed the potential of TBK1and IKKε in the treatment of metabolic diseases.

IκB kinase epsilon  /  TANK binding kinase 1  /  diabetes mellitus, type 2  /  obesity  /  non-alcoholic fatty liver disease
Xiang-Hong Wang, Xiu-Lan Zou, Qian He. Research progress in mechanism of IKKε and TBK1 in obesity, diabetes and NAFLD[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (10) : 1051 -1055 . DOI: 10.11855/j.issn.0577-7402.2021.10.16
Funding
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  • National Natural Science Foundation of China(82100473)
  • Scientific Research Project of Health Commission of Hubei Province(WJ2019M064)
  • Humanities and Social Science Research Key Project of Hubei Province(18D023)
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Year 2021 volume 46 Issue 10
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.10.16
  • Receive Date：2021-03-01
  • Online Date：2025-12-19
  • Published：2021-10-28
Article Data
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History
  • Received：2021-03-01
  • Revised：2021-07-10
Funding
National Natural Science Foundation of China(82100473)
Scientific Research Project of Health Commission of Hubei Province(WJ2019M064)
Humanities and Social Science Research Key Project of Hubei Province(18D023)
Affiliations
    1Department of Endocrinology, the Third Clinical Medical College of Three Gorges University/Gezhouba Central Hospital of Sinopharm, Yichang, Hubei 443000, China
    2Department of Geriatrics, the People's Hospital of China Three Gorges University/the First Hospital of Yichang, Yichang, Hubei 443000, China

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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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