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Research progress on the role of superficial zone cartilage-derived stem/progenitor cells in osteoarthritis
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Wei Xu, Dong-Fa Liao, Ning Xia, Da Liu*, Wei Wang, Wei Zheng
Medical Journal of Chinese People’s Liberation Army | 2021, 46(10) : 1045 - 1050
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(10): 1045-1050
• Review •
Research progress on the role of superficial zone cartilage-derived stem/progenitor cells in osteoarthritis
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Wei Xu, Dong-Fa Liao, Ning Xia, Da Liu*, Wei Wang, Wei Zheng
Affiliations
  • Department of Orthopedics, the General Hospital of Western Theater Command of PLA, Chengdu 610083, China
Published: 2021-10-28 doi: 10.11855/j.issn.0577-7402.2021.10.15
Outline
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Osteoarthritis (OA) is a degenerative disease causing irreversible progressive destruction of articular cartilage,and still no effective treatment at present. The development of stem cell technology has brought light to the treatment of OA, but the investigate of using exogenous stem cells to repair or regenerate cartilage faces many difficulties, as the chondroid tissue produced by exogenous stem cells is different from the normal articular cartilage in terms of biological characteristics and function. To solve this problem, researchers have proposed mobilizing endogenous stem cells of articular cartilage to promote self-healing of the defect sites. Although articular cartilage lacks intrinsic reparative ability, numerous studies have confirmed the existence of cartilage-derived stem/progenitor cells (CSPCs) in the superficial zone (SPZ) of cartilage. The research progress of superficial zone cartilage-derived stem/progenitor cells (SPZ-CSPCs) and their roles in OA were reviewed in present paper.

osteoarthritis  /  articular superficial zone  /  cartilage-derived stem/progenitor cells  /  cartilage regeneration  /  proteoglycan 4
Wei Xu, Dong-Fa Liao, Ning Xia, Da Liu, Wei Wang, Wei Zheng. Research progress on the role of superficial zone cartilage-derived stem/progenitor cells in osteoarthritis[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (10) : 1045 -1050 . DOI: 10.11855/j.issn.0577-7402.2021.10.15
Funding
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  • National Natural Science Foundation of China(81802206)
  • Military Health Care General Program(19BJZ11)
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Year 2021 volume 46 Issue 10
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.10.15
  • Receive Date：2021-04-07
  • Online Date：2025-12-19
  • Published：2021-10-28
Article Data
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History
  • Received：2021-04-07
  • Revised：2021-08-31
Funding
National Natural Science Foundation of China(81802206)
Military Health Care General Program(19BJZ11)
Affiliations
    Department of Orthopedics, the General Hospital of Western Theater Command of PLA, Chengdu 610083, China

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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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