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Objective To compare the clinical biochemical features, metabolic abnormalities, difference of hormone level and related factors between male and female patients with subclinical Cushing's syndrome (SCS). Methods The clinical data of 118 SCS patients (38 males and 80 females), admitted in the Department of Endocrinology, the First Medical Center of Chinese PLA General Hospital from January 2010 to January 2020, were retrospectively analyzed. The clinical characteristics, biochemical indices, metabolic disturbance, circadian rhythm of plasma adrenocorticotropic hormone (ACTH) and cortisol levels (ACTH-F),ACTH and cortisol levels at 08:00 am. after 1 mg dexamethasone suppression test (1 mg DST) and classical low-dose dexamethasone suppression test (low-dose DST) were compared between male and female SCS patients. Logistic regression analysis of F00:00, 1 mg DST-F08:00 and low-dose DST-F08:00 levels was performed for SCS patients of different genders. Results The BMI, triglyceride level and the proportion of abnormal glucose metabolism were obviously higher in male SCS patients than those in female patients[(28.08±8.30) kg/m2 vs. (25.57±3.76) kg/m2, P=0.026; (1.68±1.04) mmol/L vs. (1.35±0.69) mmol/L, P=0.045 and 60.5% vs. 37.5%, P=0.019], while no statistical difference existed between male and female patients in age, course of SCS, blood pressure levels, morbidity of hypertension, bone density and bone metabolic markers etc. The 1mg DST-F08:00 and low-dose DST-F08:00 were significantly higher in female than those in male SCS patients, and the significant difference still existed after adjusting for age, onset age, BMI and course of disease. Meanwhile, no significant effect was detected on F00:00, 1mg DST-F08:00 and low-dose DST-F08:00 between premenopausal and postmenopausal female patients. Conclusion The BMI, triglyceride level and the proportion of abnormal glucose metabolism were lower in female than in male SCS patients, but the F00:00, 1mg DST-F08:00 and low-dose DST-F08:00 were higher in female than in male SCS patients, and such differences still existed after adjusting for age, onset age, BMI and course of disease.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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