Objective To analyze the expression of chemerin and Sprouty1 proteins in common psoriasis lesion tissues and their correlation with the severity of the disease. Methods Sixty-eight patients with common psoriasis who received treatment at the dermatology outpatient clinic of the Wuxi Fifth People's Hospital and the Affiliated Hospital of Jiangnan University from February 2018 to November 2020 were selected as the experimental group, and another 68 healthy individuals who underwent physical examination at the dermatology outpatient clinics of the two hospitals during the same period were selected as the control group. The skin lesions of the trunk or limbs of patients with psoriasis vulgaris and normal skin tissues of healthy subjects were collected. Immunohistochemistry and Western blotting were used to detect the expression of chemerin and Sprouty1 protein in skin tissues, and RT-PCR was used to detect the relative expression of chemerin and Sprouty1 mRNA in skin tissues, and Pearson correlation was used to analyze the correlation between the expression of chemerin and Sprouty1 protein with the psoriasis area and severity index (PASI). Results The results of immunohistochemical assay showed that chemerin and Sprouty1 proteins were expressed in the skin tissues of both groups. Chemerin protein was strongly expressed in the adipose tissue of the skin lesions in experimental group, and in the subcutaneous adipose tissue of the control group with a small amount of expression; Sprouty1 protein was expressed in the cell membrane of the granular layer cells of the skin lesions in experimental group with a small amount of expression, and in control group, Sprouty1 protein was strongly expressed in the cell membrane and cytoplasm of the whole epidermal layer cells. The relative expressions of chemerin mRNA (1.478±0.14 vs. 0.858±0.08, P<0.001) and protein (1.138±0.12 vs. 0.789±0.06, P<0.001) were significantly higher in experimental group than in control group, and the relative expressions of Sprouty1 mRNA (0.837±0.04 vs. 1.346±0.09, P<0.001) and protein (0.646±0.05 vs. 1.212±0.12, P<0.001) were significantly lower than that of control group. Pearson correlation analysis showed that the relative expression of chemerin protein was positively correlated with PASI score (r=0.536, P<0.05), and the relative expression of Sprouty1 protein was negatively correlated with PASI score (r=-0.619, P<0.05). Conclusion The relative expression of chemerin and Sprouty1 protein in the lesion tissue of common psoriasis correlated with PASI score.