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Objective To observe the effect of rifaximin with Live Combined Bacillus Subtilis and Enterococcus Faecium enteric-coated capsules on diarrhea-predominant irritable bowel syndrome (IBS-D) in patients with small intestinal bacterial overgrowth (SIBO). Methods From July 2018 to December 2019, 114 IBS-D patients with SIBO were randomly divided into probiotics group (n=64) and combined group (n=50). The probiotics group was treated by Live Combined Bacillus Subtilis and Enterococcus Faecium enteric-coated capsules, while the combined group was treated by rifaximin with Live Combined Bacillus Subtilis and Enterococcus Faecium enteric-coated capsules. The treatment lasted for 14 days. After treatment, the symptom and serum cytokines were compared between the two groups. Results Before treatment, there were no significant differences in the symptom and accompanied symptoms between the two groups (P>0.05). After treatment, the frequency of abdominal pain, the degree of abdominal distension, the obstruction of intestinal symptoms in life, the symptom severity scale (SSS) total score, the number of patients with emergency defecation and mucus stool of the two groups were relieved or reduced as compared with pre-treatment,and the degree of abdominal pain, the number of patients with abdominal distension in the combined group were relieved or reduced than those before treatment (P<0.05). At the same time, the combined group was superior to the probiotics group in the degree of abdominal pain, the frequency of abdominal pain, the degree of abdominal distension, the SSS total score, the number of mild cases,and the number of patients with abdominal distension (P<0.05). The levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α),D-lactic acid (D-LA) and lipopolysaccharide (LPS) in the two groups were lower than those before treatment, and the levels of IL-6,TNF-α and LPS in combined group were lower than those in probiotics group (P<0.05). The negative conversion rate of SIBO in combined group was higher than that in probiotics group (76.0% vs. 46.9%), and the difference was statistically significant(P<0.05). Conclusions Both Live Combined Bacillus Subtilis and Enterococcus Faecium enteric-coated capsules and rifaximin can reverse SIBO and relieve IBS-D symptoms. The effect of the combination of the two drugs is better than that of the single use of the capsules. IBS-D with SIBO is a reasonable indication for rifaximin.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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