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Objective To investigate the expression of serum copeptin (CPP), secretory phospholipase A2-X (sPLA2-X)and pro- and anti-inflammatory cytokines in bronchiectasis (BCS) patients with non-tuberculosis mycobacterium infection (NTM). Methods One hundred and ten BCS patients admitted to Department of Respiratory Medicine in Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine from January 2017 to June 2020 were enrolled, 73 patients with BCS only as the simple BCS group, 37 BCS patients with NTM infection as the NTM infection group, according to the degree of expansion, the patients in the NTM infection group were divided into mildly dialated group (n=10), moderately dialated group (n=16) and severely dialated group (n=11), and 40 healthy volunteers were selected as the control group. The serum levels of CPP, sPLA2-X, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin (IL)-1β, IL-4, IL-6, IL-10, and IL-17A were detected. Results The serum levels of CPP, sPLA2-X, TNF-α, IFN-γ, IL-1β, IL-4, IL-6, IL-10 and IL-17A in simple BCS group and NTM infection group were significantly higher than those in control group, and those in NTM infection group were higher than those in simple BCS group (P<0.05). The serum levels of CPP, sPLA2-X, TNF-α, IFN-γ, IL-1β, IL-4, IL-6, IL-10 and IL-17A in severely dilated group were significantly higher than those in mildly and moderately dilated groups, and the levels of CPP, sPLA2-X, TNF-α, IFN-γ, IL-1β, IL-4 and IL-17A in moderately dilated group were significantly higher than those in mildly dilated group (P<0.05). Conclusion The expression levels of serum CPP, sPLA2-X and pro- and anti-inflammatory cytokines in BCS patients complicated with NTM infection are significantly elevated, which can facilitate the evaluation of severity of disease and provide guidance of clinical medication.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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