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Research progress on the role of SDF-1/CXCR4 in intervertebral disc degeneration
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Hai-Jing Hao1, Hao-Hui Wang1, Xin-Xing Yan1, Shi-Wen Li1, Lu Xu2, Xiao-Qi Liu1, *
Medical Journal of Chinese People’s Liberation Army | 2021, 46(11) : 1153 - 1158
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(11): 1153-1158
• Review •
Research progress on the role of SDF-1/CXCR4 in intervertebral disc degeneration
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Hai-Jing Hao1, Hao-Hui Wang1, Xin-Xing Yan1, Shi-Wen Li1, Lu Xu2, Xiao-Qi Liu1, *
Affiliations
  • 1Department of Orthopedics, the Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China
  • 2Department of Neurology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China
Published: 2021-11-28 doi: 10.11855/j.issn.0577-7402.2021.11.15
Outline
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Low back pain has become a public health problem worldwide. Intervertebral disc degeneration (IDD) is the main cause of low back pain, however, the molecular mechanism of IDD has not been fully elucidated. Stromal cell-derived factor-1(SDF-1) and its receptor C-X-C motif chemokine receptor-4 (CXCR4) are highly expressed in degenerative disc tissues and are believed to mediate the occurrence and development of IDD, including disc angiogenesis, inflammatory response, stromal cell metabolism, apoptosis and other pathological processes. In recent years, SDF-1/CXCR4 have also been used in tissue engineering research such as disc regeneration. Therefore, actively exploring the role of SDF-1/CXCR4 in IDD is of great significance for elucidating the molecular mechanism of IDD and studying new strategies for the treatment of IDD. The research progress in recent years has been reviewed in present paper of SDF-1/CXCR4 in IDD and intervertebral disc regeneration, in order to provide a basis for intensive study of the molecular mechanism of IDD and provide new ideas for early targeted treatment of IDD.

stromal cell-derived factor-1  /  intervertebral disc degeneration  /  angiogenesis  /  intervertebral disc regeneration
Hai-Jing Hao, Hao-Hui Wang, Xin-Xing Yan, Shi-Wen Li, Lu Xu, Xiao-Qi Liu. Research progress on the role of SDF-1/CXCR4 in intervertebral disc degeneration[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (11) : 1153 -1158 . DOI: 10.11855/j.issn.0577-7402.2021.11.15
Funding
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  • Heilongjiang Provincial Education Reform General Project(SJGY20190429)
  • Heilongjiang Provincial Education Reform General Project(SJGY20190430)
  • Horizontal Project of the Second Affiliated Hospital of Harbin Medical University(070500020146)
  • Horizontal Project of the Second Affiliated Hospital of Harbin Medical University(070500020278)
  • Standardized Training of Residents of the Second Affiliated Hospital of Harbin Medical University(2020020208)
  • Standardized Training of Residents of the Second Affiliated Hospital of Harbin Medical University(2020020223)
Appendix
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Year 2021 volume 46 Issue 11
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150
58
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.11.15
  • Receive Date：2021-03-05
  • Online Date：2025-12-19
  • Published：2021-11-28
Article Data
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History
  • Received：2021-03-05
  • Revised：2021-07-28
Funding
Heilongjiang Provincial Education Reform General Project(SJGY20190429)
Heilongjiang Provincial Education Reform General Project(SJGY20190430)
Horizontal Project of the Second Affiliated Hospital of Harbin Medical University(070500020146)
Horizontal Project of the Second Affiliated Hospital of Harbin Medical University(070500020278)
Standardized Training of Residents of the Second Affiliated Hospital of Harbin Medical University(2020020208)
Standardized Training of Residents of the Second Affiliated Hospital of Harbin Medical University(2020020223)
Affiliations
    1Department of Orthopedics, the Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China
    2Department of Neurology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China

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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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