The coronary artery functional evaluation indicators have been used recent years to evaluate the physiological function and judge the severity of coronary lesion, and provide the strategy of revascularization for patients with coronary atherosclerotic heart disease (CHD). As an invasive functional index, the efficiency of fractional flow reserve (FFR) has been widely testified by a large number of literature. However, due to its limitation in application, some FFR-based novel functional evaluation indices formed such as instantaneous wave-free reserve (iFR) and quantitative flow ratio (QFR). These indicators have their own characteristics, and provides some guidance and application value in revascularization for CHD patients although they haven't been widely used in clinical practice. The characteristics of coronary artery functional evaluation indicators, the assess capabilities of FFR,iFR and QFR to diagnosis and prognosis as well as strengths and weaknesses, the other novel functional evaluation indices, and the latest application progress of these functional indices in clinical prognosis evaluation have been reviewed in present paper, so as to guide the use of specific evaluation indicators under specific conditions, or combined use of anatomical and functional evaluation indicators to establish revascularization model to reduce false positive and/or false negative rates, so as to improve the accuracy of diagnosis.