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Objective To analyze the chromosome karyotype and Y chromosome microdeletion of male infertility. Methods Retrospective analysis of the clinical test data of 550 infertile patients who were treated at the Reproductive Center of the Sixth Medical Center of Chinese PLA General Hospital from September 2018 to December 2020. Among them, there were 187 patients of azoospermia and 363 patients of oligozoospermia (90 patients of very severe oligospermia, 101 patients of severe oligospermia, 172 patients of mild to moderate oligozoospermia). Two hundred and forty-six normal males were included as controls.Everyone underwent peripheral blood chromosome karyotype and Y chromosome microdeletion examinations. Among them, 156 patients of azoospermia, 70 patients of very severe oligospermia, 75 patients of severe oligospermia and 75 patients of normal men were tested for sex hormones [luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), testosterone (T)].The sex hormone levels of different sperm concentrations and Y chromosome microdeletion population were compared. Results Among 550 infertile patients and 246 normal men, there were 62 patients of karyotype abnormalities or chromosomal normal polymorphisms, among which: 28 patients of chromosomal abnormalities; 34 patients of chromosomal normal polymorphisms. A total of 38 patients of Y chromosome microdeletion were detected in 550 infertile patients, 17 patients of azoospermia, 18 patients of very severe oligospermia, 2 patients of severe oligospermia and, 1 patient of mild to moderate oligospermia, AZFc region deletion is the most common type. In patients with azoospermia, very severe oligospermia and severe oligospermia, the level of FSH in those with Y chromosome microdeletion is higher than that of those without Y chromosome microdeletion (P=0.032). Conclusions Chromosomal abnormalities can occur in male infertile patients. The incidence of Y chromosome microdeletion is relatively high in male infertile patients. Genetic examination can help to determine whether they have genetic diseases, so as to choose appropriate treatment methods and assisted reproduction methods.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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