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Cohort study on reproductive factors and risk of type 2 diabetes mellitus in women
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Meng-Ran Guo1, 2, Xu-Lei Tang2, Hong-Xia Che3, Cong-Hui Guan2, Nan Zhao2, Song-Bo Fu2, Li-Juan Liu2, Hang Min1, 2, Yue Ye1, 2, Xiao-Shuang Xu1, 2, Dong-Hu Zhen2, *
Medical Journal of Chinese People’s Liberation Army | 2021, 46(12) : 1196 - 1204
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(12): 1196-1204
• Clinical Research •
Cohort study on reproductive factors and risk of type 2 diabetes mellitus in women
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Meng-Ran Guo1, 2, Xu-Lei Tang2, Hong-Xia Che3, Cong-Hui Guan2, Nan Zhao2, Song-Bo Fu2, Li-Juan Liu2, Hang Min1, 2, Yue Ye1, 2, Xiao-Shuang Xu1, 2, Dong-Hu Zhen2, *
Affiliations
  • 1The First Clinical Medical College of Lanzhou University, Lanzhou 730030, China
  • 2Department of Endocrinology, the First Hospital of Lanzhou University, Lanzhou 730030, China
  • 3Department of Endocrinology, the Third People's Hospital of Gansu Province, Lanzhou 730030, China
Published: 2021-12-28 doi: 10.11855/j.issn.0577-7402.2021.12.05
Outline
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Objective To explore the relationship between the reproductive factors (such as the number of pregnancy,number of birth, abortion, lactation, menarche age, menopausal age and childbearing years) and female type 2 diabetes mellitus(T2DM). Methods Based on the data of cohort study REACTION in Lanzhou, an epidemiological investigation was performed among residents aged 40-75 years in Tianqingjiayuan, Zhangguang and Wuquanshan communities of Lanzhou City in May 2011.Reproductive history and menstrual history were determined by questionnaire. A total of 7094 women were with complete investigation data, including 2963 with normal baseline glucose tolerance who were followed up for 5 years for the occurrence of outcome event T2DM; Logistic regression and Cox risk regression analysis were employed to explore the relation between reproductive related factors and female T2DM. Results The risk of T2DM obviously increased in women with more gestational number and parturient times, especially when the gestational number and parturient times were more than 3, the risk of T2DM increased about 1.6 times, and the impact of parturient times was more significant on female T2DM (Pregnancy number 2, 3, ≥4, HR: 1.08, 1.26, 1.60; 95%CI 0.68-1.72, 1.07-1.99, 1.01-2.45; P=0.000. Parturient times 2, 3, ≥4, HR: 1.21, 1.60, 1.65; 95%CI 1.08-1.69, 1.09-2.78, 1.11-2.43; P=0.000). Abortions did not affect the incidence of female T2DM, and there was no correlation between the cumulative level of estrogen (menarche age, menopause age, childbearing years) and female T2DM. In addition, lactation was a better protective factor for women from T2DM, and may reduced the risk of female T2DM by about 30% (HR=0.70, 95%CI 0.46-0.96, P=0.001). Conclusions Pregnancy and parturient times were the risk factors of T2DM in women. With the increase of pregnancy and parturient times, the risk of T2DM increased significantly; Lactation is the protective factor of female T2DM.

diabetes mellitus, type 2  /  pregnancy  /  parity  /  abortions  /  lactation  /  female  /  cohort study
Meng-Ran Guo, Xu-Lei Tang, Hong-Xia Che, Cong-Hui Guan, Nan Zhao, Song-Bo Fu, Li-Juan Liu, Hang Min, Yue Ye, Xiao-Shuang Xu, Dong-Hu Zhen. Cohort study on reproductive factors and risk of type 2 diabetes mellitus in women[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (12) : 1196 -1204 . DOI: 10.11855/j.issn.0577-7402.2021.12.05
Funding
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  • National Standardized Metabolic Disease Management Center Special Research Fund(2018-mmczxjj-3)
  • Natural Science Foundation of Gansu Province(21JR1RA096)
  • Gansu Endocrine Disease Clinical Medical Research Center Project(20JR10FA667)
Appendix
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Year 2021 volume 46 Issue 12
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.12.05
  • Receive Date：2021-08-01
  • Online Date：2025-12-18
  • Published：2021-12-28
Article Data
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History
  • Received：2021-08-01
  • Revised：2021-10-09
Funding
National Standardized Metabolic Disease Management Center Special Research Fund(2018-mmczxjj-3)
Natural Science Foundation of Gansu Province(21JR1RA096)
Gansu Endocrine Disease Clinical Medical Research Center Project(20JR10FA667)
Affiliations
    1The First Clinical Medical College of Lanzhou University, Lanzhou 730030, China
    2Department of Endocrinology, the First Hospital of Lanzhou University, Lanzhou 730030, China
    3Department of Endocrinology, the Third People's Hospital of Gansu Province, Lanzhou 730030, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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