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Objective To study the clinical features, treatment plan, treatment strategy and prognosis of renal clear cell carcinoma in nasal cavity and paranasal sinuses. Methods Five cases of renal clear cell carcinoma in nasal cavity and paranasal sinuses from 2005 to 2020 were retrospectively analyzed. The clinical features, such as age, gender, location of disease, duration of disease and so on, were analyzed. The clinical manifestations, treatment plan and prognosis were fully discussed, and the literature results analyzed comprehensively. Results All the 5 patients were male, and the onset age of nasal cavity and paranasal sinuses ranged from 49 to 81 years old. All the 5 patients had recurrent epistaxis, and one of them was accompanied with visual loss. The site of the disease was maxillary sinus in 2 cases, ethmoid sinus and sphenoid sinus in 1 case, ethmoid sinus and frontal sinus in 2 cases.One case with nasal tumor as the first symptom, renal cell carcinoma was found during comprehensive physical examination, and then the renal cell carcinoma was treated with B-ultrasound-guided intraperitoneal perfusion and microwave ablation; four cases with nasal tumor occurred later than renal cell carcinoma, and all had radical operation of kidney in early years. All the 5 patients underwent radical resection of nasal cavity and paranasal sinus tumor. Among them, 3 cases were treated with oral targeted drugs,and 1 case was treated with local radiotherapy, but all of them had no obvious effect. As of July 2020, 1 patient lost contact, 2 patients died and 2 patients survived with tumor. Conclusions Renal clear cell carcinoma in nasal cavity and paranasal sinuses is a rare disease. The main clinical symptoms were severe epistaxis and invasion of adjacent tissues and organs. This disease had no obvious effect on radiotherapy, targeted drug therapy and immunotherapy. Radical resection of nasal cavity can relieve the clinical symptoms and improve the quality of life.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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