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Research progress of the action mechanism of lncRNA UCA1 and miRNAs in digestive system tumors
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Si-Yu Wang1, Yu Wang2, *
Medical Journal of Chinese People’s Liberation Army | 2021, 46(12) : 1232 - 1238
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(12): 1232-1238
• Review •
Research progress of the action mechanism of lncRNA UCA1 and miRNAs in digestive system tumors
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Si-Yu Wang1, Yu Wang2, *
Affiliations
  • 1School of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China
  • 2Medical Research Experimental Center, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China
Published: 2021-12-28 doi: 10.11855/j.issn.0577-7402.2021.12.10
Outline
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The incidence and mortality rate of digestive system tumors showed an increasing trend year by year, which seriously threatens human life and health. Recent years, studies have found that urothelial carcinoma embryonic antigen 1 (UCA1)is a long non-coding RNA (lncRNA), its expression significantly increased in a variety of digestive system tumor tissues or cells such as gastric cancer, colorectal cancer and esophageal cancer. In addition, UCA1 can interact with miRNAs to affect the proliferation,migration, invasion, epithelial-to-mesenchymal transition (EMT), apoptosis and drug resistance of tumor cells. The research progress of the action mechanism of lncRNA UCA1 and miRNAs in digestive system tumors (including gastric cancer, colorectal cancer and esophageal cancer) is reviewed, and the application of lncRNA UCA1 as a new biomarker and therapeutic target is prospected in present paper.

long non-coding RNA  /  urothelial carcinoma embryonic antigen 1  /  miRNA  /  digestive system tumors  /  gastric cancer  /  colorectal cancer  /  esophageal cancer
Si-Yu Wang, Yu Wang. Research progress of the action mechanism of lncRNA UCA1 and miRNAs in digestive system tumors[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (12) : 1232 -1238 . DOI: 10.11855/j.issn.0577-7402.2021.12.10
Funding
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  • National Natural Science Foundation of China(81402344)
  • Youth Science and Technology Rising Star Project of Shaanxi Province(2018KJXX-096)
  • Natural Science Research Project of Shaanxi Province(2020JM-595)
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Year 2021 volume 46 Issue 12
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.12.10
  • Receive Date：2021-06-07
  • Online Date：2025-12-18
  • Published：2021-12-28
Article Data
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History
  • Received：2021-06-07
  • Revised：2021-08-12
Funding
National Natural Science Foundation of China(81402344)
Youth Science and Technology Rising Star Project of Shaanxi Province(2018KJXX-096)
Natural Science Research Project of Shaanxi Province(2020JM-595)
Affiliations
    1School of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China
    2Medical Research Experimental Center, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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