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Research progress on the role and mechanism of AMPK in myocardial fibrosis-related diseases
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Chen-Fei Li, Di Fan, Zheng Yang, Qi-Zhu Tang*
Medical Journal of Chinese People’s Liberation Army | 2021, 46(12) : 1239 - 1244
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(12): 1239-1244
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Research progress on the role and mechanism of AMPK in myocardial fibrosis-related diseases
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Chen-Fei Li, Di Fan, Zheng Yang, Qi-Zhu Tang*
Affiliations
  • Department of Cardiology, Renmin Hospital of Wuhan University/Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan 430060, China
Published: 2021-12-28 doi: 10.11855/j.issn.0577-7402.2021.12.11
Outline
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Myocardial fibrosis is a common pathological process from various cardiovascular diseases to heart failure, and multiple signal pathways are jointly involved in the development and progression of myocardial fibrosis. AMP-activated protein kinase (AMPK) is a trimer complex widely distributed in human body, which is a central regulator of energy homeostasis involving the regulation of various metabolic responses and signaling pathways in vivo. AMPK interacts with the network of signal pathways related to myocardial fibrosis and jointly mediates the complex pathophysiological changes of myocardial fibrosis. Intervention of AMPK signal pathway provides a new therapeutic idea for the prevention and treatment of myocardial fibrosis. This paper summarizes the role and possible mechanisms of AMPK in different diseases related to cardiac fibrosis. The mutual effects of AMPK in several signaling pathways is also discussed; then further talks about the potential correlations between three kinds of commonly used clinical drugs and AMPK aiming to provide a new idea for the clinical treatment of myocardial fibrosis.

myocardial fibrosis  /  AMP-activated protein kinase  /  signaling pathway  /  drug treatment
Chen-Fei Li, Di Fan, Zheng Yang, Qi-Zhu Tang. Research progress on the role and mechanism of AMPK in myocardial fibrosis-related diseases[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (12) : 1239 -1244 . DOI: 10.11855/j.issn.0577-7402.2021.12.11
Funding
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  • National Natural Science Foundation of China(81900219)
  • National Natural Science Foundation of China(81530012)
  • National Natural Science Foundation of China(81800216)
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Year 2021 volume 46 Issue 12
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.12.11
  • Receive Date：2021-03-11
  • Online Date：2025-12-18
  • Published：2021-12-28
Article Data
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History
  • Received：2021-03-11
  • Revised：2021-07-29
Funding
National Natural Science Foundation of China(81900219)
National Natural Science Foundation of China(81530012)
National Natural Science Foundation of China(81800216)
Affiliations
    Department of Cardiology, Renmin Hospital of Wuhan University/Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan 430060, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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