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Research progress on the correlation between mitochondrial quality control disorders and idiopathic pulmonary fibrosis
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Tong Feng1, 2, Xia Gao2, Bo Wang2, Wan-Cheng Li2, *
Medical Journal of Chinese People’s Liberation Army | 2022, 47(1) : 78 - 83
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(1): 78-83
• Review •
Research progress on the correlation between mitochondrial quality control disorders and idiopathic pulmonary fibrosis
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Tong Feng1, 2, Xia Gao2, Bo Wang2, Wan-Cheng Li2, *
Affiliations
  • 1Chengdu Medical College, Chengdu 610500, China
  • 2Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China
Published: 2022-01-28 doi: 10.11855/j.issn.0577-7402.2022.01.0078
Outline
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Idiopathic pulmonary fibrosis (IPF) is a chronic disease of the respiratory tract that seriously affects lung ventilation function and gas exchange function. Mitochondria is the center of energy supply and signal induction in cells, which determine the survival and/or death of cells. The cell mitochondrial quality control mechanisms mainly include mitophagy, biosynthesis and dynamics (fusion/fission) and other regulatory processes. These cellular processes maintain the stability of quality and function of mitochondria by degrading aged and damaged mitochondria, replenishing new mitochondria, and promoting the exchange of mitochondrial contents. Recent studies have shown that mitochondrial quality control plays an important role in IPF. In IPF, the dysregulation of mitochondrial quality control leads to mitochondrial dysfunction, increased production of reactive oxygen species, inducing apoptosis, enhanced mitochondrial fusion, and decreased mitochondrial autophagy and biosynthesis. This review describes the research progress on abnormal mitochondrial quality control in IPF.

idiopathic pulmonary fibrosis  /  oxidative stress  /  mitochondrial biosynthesis  /  mitochondrial dynamics  /  mitophagy
Tong Feng, Xia Gao, Bo Wang, Wan-Cheng Li. Research progress on the correlation between mitochondrial quality control disorders and idiopathic pulmonary fibrosis[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (1) : 78 -83 . DOI: 10.11855/j.issn.0577-7402.2022.01.0078
Funding
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  • Special Scientific Research Project of National Key Clinical Specialty Construction and Cultivation Department(CYFY2018GLPHX01)
Appendix
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Year 2022 volume 47 Issue 1
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.01.0078
  • Receive Date：2021-03-23
  • Online Date：2025-12-18
  • Published：2022-01-28
Article Data
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History
  • Received：2021-03-23
  • Accepted：2021-04-22
Funding
Special Scientific Research Project of National Key Clinical Specialty Construction and Cultivation Department(CYFY2018GLPHX01)
Affiliations
    1Chengdu Medical College, Chengdu 610500, China
    2Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China

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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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