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Research advances in the inflammatory responses and signaling pathways in the development and progression of intracranial aneurysms
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Dong Chu, Guang-Min Zhang, Qing-Quan Li, Ying-Bin Li*
Medical Journal of Chinese People’s Liberation Army | 2022, 47(1) : 89 - 96
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(1): 89-96
• Review •
Research advances in the inflammatory responses and signaling pathways in the development and progression of intracranial aneurysms
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Dong Chu, Guang-Min Zhang, Qing-Quan Li, Ying-Bin Li*
Affiliations
  • Department of Neurosurgery, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China
Published: 2022-01-28 doi: 10.11855/j.issn.0577-7402.2022.01.0089
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Intracranial aneurysm (IA), characterized by distended blood vessels within the arteries, is a common vascular anomaly that frequently leads to cerebral blood vessel rupture, causing subarachnoid hemorrhage (SAH) with serious consequences.It has been found that, in addition to genetic factors, inflammatory responses induced by altered hemodynamics play a key role in the formation and rupture of IA. Subsequently, vascular inflammation can trigger a series of biochemical responses involving a variety of cells, including vascular smooth muscle cells, macrophages, lymphocytes, mast cells, and neutrophils, and involving several signaling pathways, including the PGE2-EP2-NF-κB signaling pathway, the JAK/STAT3/NF-κB signaling pathway, PI3K/Akt (PKB) signaling pathway, and AMPK/ACC signaling pathway. However, no clear conclusions have been made regarding the specific pathogenesis of IA, and immunotherapies targeting the pathogenesis of IA are still under basic research and not widely used in clinical practice. This review describes the cells, cytokines, and signaling pathways involved in the development of IA, in the hope that it will contribute to the understanding of the pathogenesis of IA and inspire the development and use of immunological drugs.

intracranial aneurysm  /  inflammatory response  /  apoptosis  /  pathology  /  pathophysiology
Dong Chu, Guang-Min Zhang, Qing-Quan Li, Ying-Bin Li. Research advances in the inflammatory responses and signaling pathways in the development and progression of intracranial aneurysms[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (1) : 89 -96 . DOI: 10.11855/j.issn.0577-7402.2022.01.0089
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  • Jiangsu Research Hospital Society-Lean Drug Use-Stone Medicine Special Research Fund Project(JY202001)
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Year 2022 volume 47 Issue 1
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.01.0089
  • Receive Date：2021-09-14
  • Online Date：2025-12-18
  • Published：2022-01-28
Article Data
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History
  • Received：2021-09-14
  • Accepted：2021-12-15
Funding
Jiangsu Research Hospital Society-Lean Drug Use-Stone Medicine Special Research Fund Project(JY202001)
Affiliations
    Department of Neurosurgery, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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