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Objective To investigate the clinical value of serum iron in diagnostic and prognostic evaluation of sepsis. Methods Retrospectively analyzed 85 cases of sepsis patients and 50 sex- and age-matched non-septic patients admitted to the ICU of the First Affiliated Hospital of Dali University from September 2018 to September 2019. According to the prognosis at 28 d, 85 sepsis patients were divided into survival group (n=51) and non-survival group (n=34). Serum iron levels were compared between the two groups. Correlation analysis between serum iron and these indices as erythrocytes, hemoglobin, C-reactive protein (CRP), procalcitonin (PCT), interleukin-1β (IL-1β), sequential organ failure assessment (SOFA) scores were performed. The receiver operating characteristic curves (ROC) were plotted to evaluate the ability of serum iron in the diagnosis and prognosis evaluation of sepsis. Kaplan-Meier survival analysis was conducted comparing the survival rates between the patients with different levels of serum iron. Cox proportional hazards regression model was used to screen the risk factors for prognosis of the patients with sepsis. Results The serum iron levels were much lower in the septic patients [8.55(4.80, 15.53) μmol/L] than those in the controls [5.30(3.15,7.90) μmol/L]. And a significantly reduced serum iron level was observed in septic patients who died [4.45(1.80, 6.88) μmol/L]than survival patients [6.30(3.80, 9.50) μmol/L]. ROC analysis indicated that the serum iron exhibited the capability to identify individuals with sepsis, with an area under curve (AUC) of 0.71, and estimated prognosis of sepsis patients, with an AUC of 0.70.Kaplan-Meier survival analysis showed that lower serum iron levels (<2.5 μmol/L) were correlated with poor 28-day survival in septic patients (P=0.003). Spearman correlation analysis suggested a significant negative correlation between serum iron levels and IL-1β levels (r=–0.51, P<0.001). Additionally, univariate Cox proportional hazards regression model suggested that lower serum iron level was a risk factor for sepsis (HR=0.86, P=0.009). Conclusion Serum iron is useful in predicting the 28-day mortality among sepsis patients, especially those with serum iron less than <2.5 μmol/L.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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