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Research progress on the effect of histone deacetylase on pulmonary arterial hypertension
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Dan Wang1, 2, Fang-Wei Li1, Yi-Xin Wan1, *
Medical Journal of Chinese People’s Liberation Army | 2022, 47(2) : 192 - 196
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(2): 192-196
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Research progress on the effect of histone deacetylase on pulmonary arterial hypertension
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Dan Wang1, 2, Fang-Wei Li1, Yi-Xin Wan1, *
Affiliations
  • 1Respiratory Department, the Second Hospital of Lanzhou University, Lanzhou 730030, China
  • 2Respiratory Deparment, the Second Clinical Medical College of Lanzhou University, Lanzhou 730030, China
Published: 2022-02-28 doi: 10.11855/j.issn.0577-7402.2022.02.0192
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Pulmonary arterial hypertension (PAH) is a progressive disease with poor prognosis, which may lead to right heart dysfunction, resulting in a series of clinical symptoms and even death, and there is still a lack of effective treatment. The etiology of PAH is complex, in which epigenetic changes play an important role in its pathogenesis. Histone acetylation modification is one of the most widely and deeply studied epigenetic modifications. The histone acetylation is mainly regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), which play a key role in chromatin and gene regulation, and is closely related to the occurrence of PAH. Targeted histone acetylation pathway has a certain therapeutic potential for PAH. This article reviews the research progress on the effect of HDACs on PAH, in order to further understand the pathogenesis of PAH and provide a new direction of treatment.

histone deacetylases  /  pulmonary arterial hypertension  /  histone deacetylase inhibitor  /  epigenetic change  /  histone modification
Dan Wang, Fang-Wei Li, Yi-Xin Wan. Research progress on the effect of histone deacetylase on pulmonary arterial hypertension[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (2) : 192 -196 . DOI: 10.11855/j.issn.0577-7402.2022.02.0192
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  • National Natural Science Foundation of China(81960014)
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Year 2022 volume 47 Issue 2
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.02.0192
  • Receive Date：2021-05-07
  • Online Date：2025-12-17
  • Published：2022-02-28
Article Data
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History
  • Received：2021-05-07
  • Accepted：2021-10-09
Funding
National Natural Science Foundation of China(81960014)
Affiliations
    1Respiratory Department, the Second Hospital of Lanzhou University, Lanzhou 730030, China
    2Respiratory Deparment, the Second Clinical Medical College of Lanzhou University, Lanzhou 730030, China

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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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