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Research progress on the BCG-induced trained immunity: mechanism and role
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Pu He, Ji-Ying Tan, Fei Li, Hong-Xia Niu, Bing-Dong Zhu*
Medical Journal of Chinese People’s Liberation Army | 2022, 47(2) : 197 - 202
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(2): 197-202
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Research progress on the BCG-induced trained immunity: mechanism and role
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Pu He, Ji-Ying Tan, Fei Li, Hong-Xia Niu, Bing-Dong Zhu*
Affiliations
  • Institute of Pathogen Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
Published: 2022-02-28 doi: 10.11855/j.issn.0577-7402.2022.02.0197
Outline
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The purpose of Bacillus Calmette-Guérin (BCG) vaccination is to prevent Mycobacterium tuberculosis infection, but studies have shown that BCG activates innate immunity, causes epigenetic reprogramming and metabolic changes of myeloid cells, and forms innate immune memory or trained immunity. When bone marrow-like cells are stimulated by pathogens again, they show enhanced immune response and promote the host's nonspecific defense ability. Innate immune memory is also called training immunity. In recent years, BCG-induced innate immune memory has attracted much attention, and it will guide the design of novel vaccine. This article reviews the application of BCG in prevention and treatment of corone virus disease 2019, the non-specific protection and mechanism of BCG-mediated trained immunity.

Bacillus Calmette-Guérin  /  trained immunity  /  innate immune memory  /  epigenetic reprogramming
Pu He, Ji-Ying Tan, Fei Li, Hong-Xia Niu, Bing-Dong Zhu. Research progress on the BCG-induced trained immunity: mechanism and role[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (2) : 197 -202 . DOI: 10.11855/j.issn.0577-7402.2022.02.0197
Funding
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  • National Natural Science Foundation of China(82001675)
  • Major Project of "Thirteenth Five-Year" Scientific and Technological Research Projects(2018ZX10302302-002-003)
  • Science and Technology Projects of Gansu Province(20YF8FA072)
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Year 2022 volume 47 Issue 2
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.02.0197
  • Receive Date：2021-03-26
  • Online Date：2025-12-17
  • Published：2022-02-28
Article Data
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History
  • Received：2021-03-26
  • Accepted：2021-08-25
Funding
National Natural Science Foundation of China(82001675)
Major Project of "Thirteenth Five-Year" Scientific and Technological Research Projects(2018ZX10302302-002-003)
Science and Technology Projects of Gansu Province(20YF8FA072)
Affiliations
    Institute of Pathogen Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China

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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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