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Research progress on SGLT2 inhibitor in heart failure with preserved ejection fraction
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Xiao-Yan Jia1, Yong-Ming Liu2, *
Medical Journal of Chinese People’s Liberation Army | 2022, 47(2) : 203 - 212
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(2): 203-212
• Review •
Research progress on SGLT2 inhibitor in heart failure with preserved ejection fraction
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Xiao-Yan Jia1, Yong-Ming Liu2, *
Affiliations
  • 1The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
  • 2Department of Geriatric Cardiology, the First Hospital of Lanzhou University/Gansu Provincial Clinical Research Center for Geriatric Medicine, Lanzhou 730000, China
Published: 2022-02-28 doi: 10.11855/j.issn.0577-7402.2022.02.0203
Outline
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At present, there is a relatively complete guideline for heart failure with ejection fraction reduction (HFrEF), but there is still a lack of evidence-based medical evidence for heart failure with preserved ejection fraction (HFpEF) treatment criteria.In recent years, a large amount of evidence has emerged that a new oral hypoglycemic drug sodium-glucose cotransporter 2 inhibitor(SGLT2i) can significantly reduce the risk of cardiovascular death and the hospitalization rate of heart failure in patients with type 2 diabetes mellitus, and improve the prognosis of HFrEF. However, there is still a lack of overall understanding of the mechanism and research progress of SGLT2i in the treatment of HFpEF. This article reviews the pathological mechanism of HFpEF, the mechanism of action of SGLT2i and the related research on the treatment of HFpEF, in order to provide reference for the clinical drug treatment of HFpEF.

heart failure  /  heart failure with preserved ejection fraction  /  heart failure with reduced ejection fraction  /  sodium-glucose cotransporter 2 inhibitors
Xiao-Yan Jia, Yong-Ming Liu. Research progress on SGLT2 inhibitor in heart failure with preserved ejection fraction[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (2) : 203 -212 . DOI: 10.11855/j.issn.0577-7402.2022.02.0203
Funding
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  • Health Industry Project of Gansu Province(GSWSKY-2019-08)
  • Special Project for Local Science and Technology Development under the Leadership of the Central Committee of Gansu Province(20YF8FA079)
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Year 2022 volume 47 Issue 2
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.02.0203
  • Receive Date：2021-04-19
  • Online Date：2025-12-17
  • Published：2022-02-28
Article Data
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History
  • Received：2021-04-19
  • Accepted：2021-05-11
Funding
Health Industry Project of Gansu Province(GSWSKY-2019-08)
Special Project for Local Science and Technology Development under the Leadership of the Central Committee of Gansu Province(20YF8FA079)
Affiliations
    1The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
    2Department of Geriatric Cardiology, the First Hospital of Lanzhou University/Gansu Provincial Clinical Research Center for Geriatric Medicine, Lanzhou 730000, China

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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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