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Research progress of the modulation of leptin on the main effector cells of rheumatoid arthritis
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Xin-Xin Huang, Chun-Li Wu, Zhen Wang, Xia Li, Jing Wei*
Medical Journal of Chinese People’s Liberation Army | 2022, 47(3) : 314 - 319
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(3): 314-319
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Research progress of the modulation of leptin on the main effector cells of rheumatoid arthritis
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Xin-Xin Huang, Chun-Li Wu, Zhen Wang, Xia Li, Jing Wei*
Affiliations
  • Department of Immunology, Basic Medical College of Dalian Medical University, Dalian, Liaoning 116044, China
Published: 2022-03-28 doi: 10.11855/j.issn.0577-7402.2022.03.0314
Outline
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Leptin, a fat factor synthesized in adipose tissue, is initially worked as a hormone substance regulating body fat balance. With in depth-study, researchers found that leptin has structural homology with such cytokines as interleukin-6 (IL-6), and its receptor, Ob-R, belongs to class Ⅰ cytokine receptor superfamily. Through binding to corresponding receptor, leptin can not only regulate the food intake and energy balance, but can also regulate the immune system. Rheumatoid arthritis (RA) is one of the common autoimmune diseases caused by many genetic and environmental factors. The fundamental pathological change of RA is chronic synovial inflammation and pannus formation, and leads to the destruction of cartilage, bone and surrounding tissue. Many immune cells and resident stromal cells are involved in RA pathological progress although the exact pathogenesis of RA remained unclear. It has been proved by in vivo experiment of RA animal model that leptin is related to the joint inflammation, and may participate in the pathogenesis and process of the disease. The immunomodulatory effects of leptin on the main effector cells of RA has been reviewed in present paper, aiming to expand ideas for related research.

leptin  /  rheumatoid arthritis  /  immunoregulation
Xin-Xin Huang, Chun-Li Wu, Zhen Wang, Xia Li, Jing Wei. Research progress of the modulation of leptin on the main effector cells of rheumatoid arthritis[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (3) : 314 -319 . DOI: 10.11855/j.issn.0577-7402.2022.03.0314
Funding
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  • National Natural Science Foundation of China(82071834)
  • Natural Science Foundation of Liaoning Province(20180550789)
  • Dalian Medical University Undergraduate Innovation and Entrepreneurship Training Program(S202010161042)
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Year 2022 volume 47 Issue 3
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.03.0314
  • Receive Date：2021-07-26
  • Online Date：2025-12-17
  • Published：2022-03-28
Article Data
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History
  • Received：2021-07-26
  • Accepted：2021-09-08
Funding
National Natural Science Foundation of China(82071834)
Natural Science Foundation of Liaoning Province(20180550789)
Dalian Medical University Undergraduate Innovation and Entrepreneurship Training Program(S202010161042)
Affiliations
    Department of Immunology, Basic Medical College of Dalian Medical University, Dalian, Liaoning 116044, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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