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Objective To investigate the changes of plasma peroxiredoxin 6 (PRDX6) level in patients with polycystic ovary syndrome (PCOS) and the relativity with glucose and lipid metabolism and sex hormone levels. Methods This is a retrospective case-control study. The clinical data were collected of 47 patients with PCOS (PCOS group) admitted to the Second Affiliated Hospital of Army Medical University from January to October 2020, and of 60 healthy people undergone medical examination in the same hospital during the same period (healthy control group). The two groups were further divided into two subgroups according to body mass index (BMI). Among them, 17 cases in PCOS group had BMI ≤24 kg/m2, and 30 cases had BMI >24 kg/m2; and in healthy control group 36 cases had BMI ≤24 kg/m2, and 24 cases had BMI >24 kg/m2. The differences and correlations of plasma PRDX6 levels with glucose and lipid metabolism and sex hormone indexes between the two groups and subgroups were compared and analyzed. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of PRDX6 on glucose and lipid metabolism and sex hormone indicators. Results The plasma PRDX6 level was significantly higher in PCOS group than in healthy control group (P<0.0001). Correlation analysis showed that the PRDX6 level was positively correlated with the glucose and lipid metabolism indexes triacylglycerol (TG), low density lipoprotein (LDL), fasting insulin (FINS), glycosylated hemoglobin(HbA1c), insulin resistance index (HOMA-IR) and islets β cell function (HOMA-β), and negatively correlated with high-density lipoprotein (HDL) in all patients or when BMI >24 kg/m2 (P<0.05); When BMI ≤24 kg/m2, PRDX6 showed no relationship with glucose and lipid metabolism (P>0.05). PRDX6 was positively correlated with sex hormone indicators testosterone (T), luteinizing hormone (LH) and luteinizing hormone/follicle-stimulating hormone (LH/FSH), and negatively correlated with estradiol (E2) and progesterone (P) in all patients or when BMI >24 kg/m2 (P<0.05); When BMI ≤24 kg/m2, PRDX6 was positively correlated with T and LH/FSH, and negatively correlated with E2 and P. The area under the ROC curve (AUC) of PRDX6 for predicting HOMA-IR and sex hormone LH were 0.753 and 0.592, respectively (P<0.0001); the AUCs of PRDX6 for predicting HOMA-IR and sex hormone LH in PCOS patients were 0.917 and 0.544, respectively (P<0.0001, P=0.461). Conclusion The high level of PRDX6 expression might be a risk factor for abnormal glucose and lipid metabolism and hormone indexes in PCOS patients, so the PRDX6 factor may have a high predictive value for glucose and lipid metabolism in PCOS patients.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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