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Objective To analyze the clinical features of 9 patients with renin secreting tumor and review the related literature in order to improve the understanding, diagnosis and treatment of the disease. Methods The clinical data, diagnosis, treatment, pathological and immunohistochemical profiles of 9 patients with renin secreting tumor admitted in the First Medical Center of Chinese PLA General Hospital from January 2010 to February 2020 were retrospectively analyzed. The literature was searched by retrieving the related database from 2001 to 2020, combined with 142 similar cases collected by searching the database to analyze the clinical features of patients with renin secreting tumor. Results All the 9 patients with an average age of 22.6 years presented with hypertension, and 7 of the 9 with hypokalemia. The plasma renin levels in all the patients were significantly higher than normal range, and the plasma aldosterone levels were above the median normal reference interval. Postoperative pathological examination of all cases confirmed juxtaglomerular cell tumor. Immunohistochemical staining showed that all the tumor cell renin, vimentin and CD34 were positive, some neoplastic cells were positive for smooth muscle actin (SMA) and synaptophysin (Syn), and negative for S-100 protein (S-100) and chromogranin A (CgA). The blood pressure and serum potassium level returned to normal range in all patients after surgery. A total of 142 patients with renin secreting tumor have been reported in China from 2001 to 2020.Hypertension was the initial symptom of all the patients. Hypokalemia occurred in 87 of 142 patients. Plasma renin and aldosterone levels were above the normal range in 93 patients. No recurrence or metastasis occurred in all patients after surgery during follow-up. Conclusions Renin secreting tumor mostly is characterized as benign renal tumor with hypertension, hypokalemia, hyperreninemia and hyperaldosteronism. Surgery is preferred in treatment of this tumor for a good prognosis.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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