PDF
Full
Outline
Objective To investigate the spectrum and clinical characteristics of growth hormone(GH)-secreting pituitary tumor combined with thyroid diseases and to analyze its risk factors. Methods A retrospective study was used to analyze 133 patients with GH-secreting pituitary tumor who underwent thyroid ultrasound examination in the Second Affiliated Hospital of Army Medical University. The patients with GH-secreting pituitary tumor were divided into thyroid abnormal group and normal thyroid group. The clinical data of the two groups were compared. The correlation between variables was analyzed by multiple linear regression, and the risk of GH-secreting pituitary tumor with thyroid disease was analyzed by binary logistic regression. Results Among the 133 GH-secreting pituitary tumor patients, 108 cases (81.2%) had thyroid diseases. (1) Classified by thyroid ultrasonography, 51 (38.3%) with nodular goiters, 44 cases (33.1%) with simple thyroid nodules, 5 cases (3.8%) with goiters,33 cases (24.8%) without thyroid ultrasound abnormalities. (2) Classified by thyroid function, 34 cases (25.6%) with thyroid dysfunction, 99 cases (74.4%) with normal thyroid function. (3) Classified by pathology of thyroid, 10 cases accomplished thyroid pathological examination, 2 cases (1.5%) with thyroid cancers, 8 cases (6.0%) with benign thyroid nodules, 123 cases (92.5%)without pathological examination. (4) Classified by nosology, 22 cases (16.5%) with thyroiditis, 111 patients (83.5%) with normal thyroid immunological indicators. Univariate analysis showed that the nadir GH levels in patients with GH-secreting pituitary tumor was higher in the thyroid abnormality group than in the normal thyroid group (P<0.05). Multiple linear regression analysis showed that thyroid volume was positively correlated with insulin-like growth fator-1 (IGF-1), age, body mass index (BMI), thyroid stimulating hormone (TSH), thyroxine (T4) and thyroglobulin (Tg), [partial regression coefficient (B)=0.000, 0.006,0.019, 0.001, –0.144, –0.002 respectively, P<0.05]. The diameter of thyroid nodule was only positively correlated with Tg and age(B=0.004 and 0.017, P<0.05). The diameter of thyroid nodule was only positively correlated with Tg and age (P<0.05). The binary logistic regression analysis showed that the patients with the higher of the nadir GH levels, BMI of 24-26 kg/m2 and the sphenoid sinus invasion score >2, the higher the risk of combined thyroid diseases was, the odds ratio (OR) was 11.450, 5.022 and 6.576, respectively. Conclusion The incidence of various thyroid diseases in patients with GH-secreting pituitary tumor was significantly high, particularly nodular goiters and simple thyroid nodules, nadir GH levels of GH-secreting pituitary tumor is an independent risk factor of thyroid diseases, sphenoid sinus invasion score may be a potential predictor.
PDF
175
76
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
