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Research progress of chimeric antigen receptor T-cell immunotherapy in the treatment of pancreatic cancer
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Dong Tu, Jie Yu, Wen-Ke Cai, Xiao-Di Luo, Yang Gao, Yu Chen, Bing-Yu Yu, Guo-Jun Luo*
Medical Journal of Chinese People’s Liberation Army | 2022, 47(4) : 419 - 426
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(4): 419-426
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Research progress of chimeric antigen receptor T-cell immunotherapy in the treatment of pancreatic cancer
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Dong Tu, Jie Yu, Wen-Ke Cai, Xiao-Di Luo, Yang Gao, Yu Chen, Bing-Yu Yu, Guo-Jun Luo*
Affiliations
  • Department of Cardiothoracic Surgery, the 920th Hospital of Joint Logistics Support Force, Kunming 650032, China
Published: 2022-04-28 doi: 10.11855/j.issn.0577-7402.2022.04.0419
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Pancreatic cancer is one of the malignant tumors of digestive system with high malignancy and poor prognosis,so is called the "king of cancer" since resulting in an extremely high mortality rate. The death cases account for more than 90% of new cases in 2020, and there is still a lack of better treatments for pancreatic cancer. Chimeric antigen receptor T cell (CAR-T)immunotherapy has achieved great success in hematological malignancies, with an overall remission rate reached more than 80%. At present, five CAR-T products have been approved by the US FDA for listing, which marks a new era of anti-cancer road. In recent years, many scientists have focused their attention on CAR-T therapy to treatment of pancreatic cancer and have made good progress.The recent progress was summarized in present article of CAR-T therapy in treatment of pancreatic cancer including the selection of CAR-T targets, existed early clinical research, safety assessment, existed problems and challenges, etc., aiming to provide new ideas for pancreatic cancer immunotherapy.

pancreatic cancer  /  chimeric antigen receptor T cell immunotherapy  /  targets selection  /  safety
Dong Tu, Jie Yu, Wen-Ke Cai, Xiao-Di Luo, Yang Gao, Yu Chen, Bing-Yu Yu, Guo-Jun Luo. Research progress of chimeric antigen receptor T-cell immunotherapy in the treatment of pancreatic cancer[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (4) : 419 -426 . DOI: 10.11855/j.issn.0577-7402.2022.04.0419
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.04.0419
  • Receive Date：2021-04-09
  • Online Date：2025-12-17
  • Published：2022-04-28
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  • Received：2021-04-09
  • Accepted：2021-05-26
Affiliations
    Department of Cardiothoracic Surgery, the 920th Hospital of Joint Logistics Support Force, Kunming 650032, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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