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The pathological mechanism of celiac disease is not completely clear, and environmental factors may trigger the occurrence of intestinal inflammatory response in genetic susceptible individuals. Recent researches indicated that, due to the coordinated action of multiple factors such as abnormal intestinal mucosal barrier function and intestinal microbial changes, the homeostasis of intestinal environment is imbalanced, which aggravates the severity of the disease. Gluten-free diet combined with probiotics and other drugs would regulate intestinal microbiota and be conducive to resume intestinal mucosal barrier function,thereafter effectively alleviate the clinical symptoms of patients. However, both the composition of intestinal flora and its role in pathogenesis of the disease needs further consideration. To explore the pathological mechanism of celiac disease and targeted treatment for those factors will become a new perspective for precise prevention and treatment of celiac disease.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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