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Research progress in the relationship of autophagy and blood brain barrier
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Yu-Qi Wang, Peng Xu, Hong-Jie Fan, Xiao-Min Wang*
Medical Journal of Chinese People’s Liberation Army | 2022, 47(5) : 518 - 523
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(5): 518-523
• Review •
Research progress in the relationship of autophagy and blood brain barrier
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Yu-Qi Wang, Peng Xu, Hong-Jie Fan, Xiao-Min Wang*
Affiliations
  • School of Basic Medicine, Zunyi Medical University, Zunyi, Guizhou 563000, China
Published: 2022-05-28 doi: 10.11855/j.issn.0577-7402.2022.05.0518
Outline
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Autophagy has a certain degree of protective effect on cells, but excessive autophagy can lead to programmed cell death, which is called Ⅱ programmed cell death. The blood brain barrier (BBB) plays a protective role between the brain and the peripheral circulation, which helps the inflow and outflow of molecules and ions to maintain the steady state of the central nervous system. A large number of studies have shown that autophagy plays an important role in BBB dysfunction, on the one hand, autophagy can damage or protect the integrity of BBB, and on the other hand, autophagy can also affect the passage of drugs,pathogens and other substances through BBB. Therefore, regulating autophagy level by targeting specific regulatory molecules in autophagy mechanism may affect the function of BBB, and then affect the occurrence and development of central nervous system diseases. The recent advances in the relationship between autophagy and BBB have been reviewed in present paper for hoping to provide new ideas for the prevention and treatment of diseases related to BBB injury.

autophagy  /  blood-brain barrier  /  pathogen  /  drug
Yu-Qi Wang, Peng Xu, Hong-Jie Fan, Xiao-Min Wang. Research progress in the relationship of autophagy and blood brain barrier[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (5) : 518 -523 . DOI: 10.11855/j.issn.0577-7402.2022.05.0518
Funding
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  • National Natural Science Foundation of China(31860706)
  • Young Scientific and Technological Talents Growth Project of Guizhou Provincial Education Department(KY[2018]222)
  • National Undergraduate Innovation and Entrepreneurship Project(202010661004)
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Year 2022 volume 47 Issue 5
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.05.0518
  • Receive Date：2021-05-08
  • Online Date：2025-12-17
  • Published：2022-05-28
Article Data
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History
  • Received：2021-05-08
  • Accepted：2021-06-22
Funding
National Natural Science Foundation of China(31860706)
Young Scientific and Technological Talents Growth Project of Guizhou Provincial Education Department(KY[2018]222)
National Undergraduate Innovation and Entrepreneurship Project(202010661004)
Affiliations
    School of Basic Medicine, Zunyi Medical University, Zunyi, Guizhou 563000, China

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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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