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Research progress in the treatment of glioblastoma by nose-to-brain delivery
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Wen-Wen Li1, Rui Lai2, Qi Liu3, Hai-Long Zhao1, *
Medical Journal of Chinese People’s Liberation Army | 2022, 47(5) : 511 - 517
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(5): 511-517
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Research progress in the treatment of glioblastoma by nose-to-brain delivery
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Wen-Wen Li1, Rui Lai2, Qi Liu3, Hai-Long Zhao1, *
Affiliations
  • 1Department of Pathophysiology, School of Preclinical Medicine, Zunyi Medical University, Zunyi, Guizhou 563000, China
  • 2First Clinical College, Zunyi Medical University, Zunyi, Guizhou 563000, China
  • 3School of Stomatology, Zunyi Medical University, Zunyi, Guizhou 563000, China
Published: 2022-05-28 doi: 10.11855/j.issn.0577-7402.2022.05.0511
Outline
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Glioblastoma (GBM) is a most common primary malignant brain tumor characterized by rapid growth and invasion of surrounding tissues. At present, the standard methods for treatment of GBM include surgical resection, radiotherapy and chemotherapy. Because the existence of blood-brain barrier (BBB) restricts the delivery of anti-cancer drugs into the brain,novel drug deliver approaches are urgently needed to improve the therapeutic effect of GBM. As a non-invasive alternative route for directly targeting the central nervous system (CNS) disease, nose-to-brain delivery could bypass the BBB and reduce the systemic side effects. Recently, several formulations have been developed for further enhancing nose-to-brain transport, mainly with the use of nanostructured drug delivery systems. The application of nose-to-brain delivery combined with different anticancer drugs or methods in clinical treatment of GBM have been reviewed in present paper.

nasal delivery  /  glioblastoma  /  blood-brain barrier  /  nose-to-brain delivery  /  stem cells
Wen-Wen Li, Rui Lai, Qi Liu, Hai-Long Zhao. Research progress in the treatment of glioblastoma by nose-to-brain delivery[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (5) : 511 -517 . DOI: 10.11855/j.issn.0577-7402.2022.05.0511
Funding
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  • National Natural Science Foundation of China(31701007)
  • National Natural Science Foundation of China(82060503)
  • Postgraduate Research fund Project of Zunyi Medical University(ZYK024)
  • Science and Technology Program of Guizhou Province(QKHJZ-2019-1334)()
  • Science and Technology Fund Project of Guizhou Health Commission(gzwjkj2019-1-033)
  • Development Project of Science and Technology Talents Supported by Education Department of Guizhou Province(QJHKYZ-2017-198)
Appendix
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Year 2022 volume 47 Issue 5
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208
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.05.0511
  • Receive Date：2021-05-20
  • Online Date：2025-12-17
  • Published：2022-05-28
Article Data
Affiliations
History
  • Received：2021-05-20
  • Accepted：2021-11-05
Funding
National Natural Science Foundation of China(31701007)
National Natural Science Foundation of China(82060503)
Postgraduate Research fund Project of Zunyi Medical University(ZYK024)
Science and Technology Program of Guizhou Province(QKHJZ-2019-1334)()
Science and Technology Fund Project of Guizhou Health Commission(gzwjkj2019-1-033)
Development Project of Science and Technology Talents Supported by Education Department of Guizhou Province(QJHKYZ-2017-198)
Affiliations
    1Department of Pathophysiology, School of Preclinical Medicine, Zunyi Medical University, Zunyi, Guizhou 563000, China
    2First Clinical College, Zunyi Medical University, Zunyi, Guizhou 563000, China
    3School of Stomatology, Zunyi Medical University, Zunyi, Guizhou 563000, China

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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
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小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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